Silymarin modulates catabolic cytokine expression through Sirt1 and SOX9 in human articular chondrocytes.
Wen-Tien WuYi-Ru ChenDai-Hua LuFedor Svyatoslavovich SenatovKai-Chiang YangChen-Chie WangPublished in: Journal of orthopaedic surgery and research (2021)
SMN regulates the chondrocyte phenotype through Sirt1 and SOX9 to improve ECM homeostasis and may serve as a complementary therapy for early-stage knee OA.
Keyphrases
- early stage
- transcription factor
- stem cells
- endothelial cells
- knee osteoarthritis
- poor prognosis
- oxidative stress
- ischemia reperfusion injury
- extracellular matrix
- total knee arthroplasty
- induced pluripotent stem cells
- pluripotent stem cells
- sentinel lymph node
- squamous cell carcinoma
- binding protein
- long non coding rna
- radiation therapy
- locally advanced