Histamine- and pruritogen-induced itch is inhibited by a TRPM8 agonist: a randomized vehicle-controlled human trial.

Soyeon LeeEdward T WeiTudor SelescuAlexandru BabesJinseo ParkJincheol KimBoyoung ChungChunwook ParkChun Wook Park

Published in: The British journal of dermatology (2024)

The specific TRPM8 agonist gel effectively suppressed human skin itch induced by various pruritogens. These versatile actions suggest that cooling agents may be promising treatments for multiple forms of itch stimuli.

Keyphrases

atopic dermatitis
endothelial cells
high glucose
clinical trial
study protocol
diabetic rats
phase iii
induced pluripotent stem cells
phase ii
randomized controlled trial
pluripotent stem cells
drug induced
hyaluronic acid
open label
stress induced