Flavonoids as emerging notch signaling pathway modulators in cancer.
Atul Kumar SinghSabyasachi SenapatiPublished in: Journal of Asian natural products research (2023)
Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the chemotherapy but none got clinical approval due to severe toxicity in patients. Flavonoids inhibit NSP by inhibiting notch receptor cleavage and/or inhibiting transcriptional regulation by Notch intracellular domain (NICD). Interestingly, some flavonoids are reported to inhibit NSP by mediating the microRNA expression. NSP inhibitory flavonoid(s) in combination with standard therapy is might be an effective strategy in cancer treatment.
Keyphrases
- signaling pathway
- cell proliferation
- clinical trial
- pi k akt
- end stage renal disease
- epithelial mesenchymal transition
- ejection fraction
- newly diagnosed
- chronic kidney disease
- poor prognosis
- papillary thyroid
- induced apoptosis
- small molecule
- oxidative stress
- early onset
- prognostic factors
- binding protein
- gene expression
- squamous cell carcinoma
- patient reported outcomes
- peritoneal dialysis
- stem cells
- radiation therapy
- squamous cell
- randomized controlled trial
- mesenchymal stem cells
- rectal cancer
- locally advanced
- reactive oxygen species
- endoplasmic reticulum stress
- bone marrow