UCP1 expression in human brown adipose tissue is inversely associated with cardiometabolic risk factors.
T'ng Choong KwokLynne E RamageAlexandra KelmanKarla J SuchackiCalum D GrayLuke D BoyleScott I SempleTom MacGillivrayGillian MacNaughtDilip PatelEdwin J R van BeekRobert K SempleSonia J WakelinRoland H StimsonPublished in: European journal of endocrinology (2024)
18F-FDG uptake by BAT and UCP1 expression are preserved in young obese adults. Older subjects retain precursor cells with the capacity to form new thermogenic adipocytes. These data highlight the therapeutic potential of BAT mass expansion and activation in obesity.
Keyphrases
- adipose tissue
- poor prognosis
- insulin resistance
- risk factors
- metabolic syndrome
- weight loss
- type diabetes
- induced apoptosis
- endothelial cells
- high fat diet
- middle aged
- binding protein
- physical activity
- pet ct
- electronic health record
- long non coding rna
- weight gain
- oxidative stress
- computed tomography
- signaling pathway
- induced pluripotent stem cells
- cell death
- cell proliferation
- skeletal muscle
- pluripotent stem cells
- community dwelling
- deep learning