Molecular basis of proton-sensing by G protein-coupled receptors.
Matthew K HowardNicholas HoppeXi-Ping HuangChristian B MacdonaldEshan MehrotaPatrick Rockefeller GrimesAdam ZahmDonovan D TrinidadJustin G EnglishWillow Coyote-MaestasAashish ManglikPublished in: bioRxiv : the preprint server for biology (2024)
The protonation networks governing activation of human pH-sensing GPCRs are uncovered by integrative cryo-EM and deep mutational scanning.