Aashish Manglik

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 34

Top Topics

Respiratory Syndrome Coronavirus

Structural Basis

Electron Microscopy

Top Venues

Nature structural & molecular biology

bioRxiv : the preprint server for biology

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Matthew K Howard, Nicholas Hoppe, Xi-Ping Huang, Christian B Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes, Adam Zahm, Donovan D Trinidad, Justin G English, Willow Coyote-Maestas, Aashish Manglik
Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv : the preprint server for biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Matthew K Howard, Nicholas Hoppe, Xi-Ping Huang, Christian B Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes, Adam Zahm, Donovan D Trinidad, Justin G English, Willow Coyote-Maestas, Aashish Manglik
Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv : the preprint server for biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology (2024)
Matthew K Howard, Nicholas Hoppe, Xi-Ping Huang, Christian B Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes, Adam Zahm, Donovan D Trinidad, Justin G English, Willow Coyote-Maestas, Aashish Manglik
Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv : the preprint server for biology (2024)
Matthew K Howard, Nicholas Hoppe, Xi-Ping Huang, Christian B Macdonald, Eshan Mehrota, Patrick Rockefeller Grimes, Adam Zahm, Donovan D Trinidad, Justin G English, Willow Coyote-Maestas, Aashish Manglik
Molecular basis of proton-sensing by G protein-coupled receptors. bioRxiv : the preprint server for biology (2024)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Ziwei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature structural & molecular biology 31 (4) (2024)
Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Structural basis of odorant recognition by a human odorant receptor. Nature 615 (7953) (2023)
Claire A de March, Ning Ma, Christian B Billesbølle, Jeevan Tewari, Claudia Llinas Del Torrent, Wijnand J C van der Velden, Ichie Ojiro, Ikumi Takayama, Bryan Faust, Linus Li, Nagarajan Vaidehi, Aashish Manglik, Hiroaki Matsunami
Engineered odorant receptors illuminate structural principles of odor discrimination. bioRxiv : the preprint server for biology (2023)
Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Structural basis of odorant recognition by a human odorant receptor. Nature 615 (7953) (2023)
Christian B Billesbølle, Claire A de March, Wijnand J C van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas Del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik
Structural basis of odorant recognition by a human odorant receptor. Nature (2023)
Nicholas Hoppe, Simone Harrison, Sun-Hee Hwang, Zi-Wei Chen, Masha Karelina, Ishan Deshpande, Carl-Mikael Suomivuori, Vivek R Palicharla, Samuel P Berry, Philipp Tschaikner, Dominik Regele, Douglas F Covey, Eduard Stefan, Debora S Marks, Jeremy F Reiter, Ron O Dror, Alex S Evers, Saikat Mukhopadhyay, Aashish Manglik
GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. bioRxiv : the preprint server for biology (2023)
Dong Hee Chung, Sophie Kong, Nicholas J Young, Shih-Wei Chuo, Jamie V Shiah, Emily J Connelly, Peter J Rohweder, Alexandra Born, Aashish Manglik, Jennifer R Grandis, Daniel E Johnson, Charles S Craik
Rare antibody phage isolation and discrimination (RAPID) biopanning enables identification of high-affinity antibodies against challenging targets. Communications biology 6 (1) (2023)
Kaihua Zhang, Hao Wu, Nicholas Hoppe, Aashish Manglik, Yifan Cheng
Fusion protein strategies for cryo-EM study of G protein-coupled receptors. Nature communications 13 (1) (2022)
Bryan Faust, Christian B Billesbølle, Carl-Mikael Suomivuori, Isha Singh, Kaihua Zhang, Nicholas Hoppe, Antonio F M Pinto, Jolene K Diedrich, Yagmur Muftuoglu, Mariusz W Szkudlinski, Alan Saghatelian, Ron O Dror, Yifan Cheng, Aashish Manglik
Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature 609 (7928) (2022)
Benjamin Barsi-Rhyne, Aashish Manglik, Mark Von Zastrow
Discrete GPCR-triggered endocytic modes enable β-arrestins to flexibly regulate cell signaling. eLife 11 (2022)
Jung-Eun Shin, Adam J Riesselman, Aaron W Kollasch, Conor McMahon, Elana Simon, Chris Sander, Aashish Manglik, Andrew C Kruse, Debora S Marks
Protein design and variant prediction using autoregressive generative models. Nature communications 12 (1) (2021)
Kliment Verba, Meghna Gupta, Caleigh Azumaya, Michelle Moritz, Sergei Pourmal, Amy Diallo, Gregory Merz, Gwendolyn Jang, Mehdi Bouhaddou, Andrea Fossati, Axel Brilot, Devan Diwanji, Evelyn Hernandez, Nadia Herrera, Huong Kratochvil, Victor Lam, Fei Li, Yang Li, Henry C Nguyen, Carlos Nowotny, Tristan Owens, Jessica Peters, Alexandrea N Rizo, Ursula Schulze-Gahmen, Amber Smith, Iris Young, Zanlin Yu, Daniel Asarnow, Christian Billesbølle, Melody G Campbell, Jen Chen, Kuei-Ho Chen, Un Seng Chio, Miles Sasha Dickinson, Loan Doan, Mingliang Jin, Kate Kim, Junrui Li, Yen-Li Li, Edmond Linossi, Yanxin Liu, Megan Lo, Jocelyne Lopez, Kyle Lopez, Adamo Mancino, Frank Moss Iii, Michael Paul, Komal Pawar, Adrian Pelin, Thomas Pospiech, Cristina Puchades, Soumya Remesh, Maliheh Safari, Kaitlin Schaefer, Ming Sun, Mariano Tabios, Aye Thwin, Erron W Titus, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Feng, Kaihua Zhang, Yang Zhang, Jianhua Zhao, Fengbo Zhou, Yuan Zhou, Lorena Zuliani-Alvarez, David A Agard, Yifan Cheng, James Fraser, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R Southworth, Robert M Stroud, Danielle Swaney, Nevan J Krogan, Adam Frost, Oren S Rosenberg
CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Research square (2021)
Julian A Harris, Bryan Faust, Arisbel B Gondin, Marc André Dämgen, Carl-Mikael Suomivuori, Nicholas A Veldhuis, Yifan Cheng, Ron O Dror, David M Thal, Aashish Manglik
Selective G protein signaling driven by substance P-neurokinin receptor dynamics. Nature chemical biology (2021)
Christian B Billesbølle, Caleigh M Azumaya, Rachael C Kretsch, Alexander S Powers, Shane Gonen, Simon Schneider, Tara Arvedson, Ron O Dror, Yifan Cheng, Aashish Manglik
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms. Nature 586 (7831) (2020)
Yunxiao Zhang, Wan-Jin Lu, David P Bulkley, Jiahao Liang, Arthur Ralko, Shuo Han, Kelsey J Roberts, Anping Li, Wonhwa Cho, Yifan Cheng, Aashish Manglik, Philip A Beachy
Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proceedings of the National Academy of Sciences of the United States of America 117 (46) (2020)
Jeffrey D Whitman, Joseph Hiatt, Cody T Mowery, Brian R Shy, Ruby Yu, Tori N Yamamoto, Ujjwal Rathore, Gregory M Goldgof, Caroline Whitty, Jonathan M Woo, Antonia E Gallman, Tyler E Miller, Andrew G Levine, David N Nguyen, Sagar P Bapat, Joanna Balcerek, Sophia Anna Bylsma, Ana M Lyons, Stacy Li, Allison Wai-Yi Wong, Eva Mae Gillis-Buck, Zachary B Steinhart, Youjin Lee, Ryan Apathy, Mitchell J Lipke, Jennifer Anne Smith, Tina Zheng, Ian C Boothby, Erin Isaza, Jackie Chan, Dante D Acenas, Jinwoo Lee, Trisha A Macrae, Than S Kyaw, David Wu, Dianna L Ng, Wei Gu, Vanessa A York, Haig Alexander Eskandarian, Perri C Callaway, Lakshmi Warrier, Mary E Moreno, Justine Levan, Leonel Torres, Lila A Farrington, Rita P Loudermilk, Kanishka Koshal, Kelsey C Zorn, Wilfredo F Garcia-Beltran, Diane Yang, Michael G Astudillo, Bradley E Bernstein, Jeffrey A Gelfand, Edward T Ryan, Richelle C Charles, A John Iafrate, Jochen K Lennerz, Steve Miller, Charles Y Chiu, Susan L Stramer, Michael R Wilson, Aashish Manglik, Chun Jimmie Ye, Nevan J Krogan, Mark S Anderson, Jason G Cyster, Joel D Ernst, Alan H B Wu, Kara L Lynch, Caryn Bern, Patrick D Hsu, Alexander Marson
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nature biotechnology 38 (10) (2020)
Bei Wang, Daniel E Asarnow, Wen-Hsin Sandy Lee, Ching-Wen Huang, Bryan Faust, Patricia Miang Lon Ng, Eve Zi Xian Ngoh, Markus F Bohn, David Bulkley, Andrés Pizzorno, Hwee Ching Tan, Chia Yin Lee, Rabiatul Adawiyah Minhat, Olivier Terrier, Mun Kuen Soh, Frannie Jiuyi Teo, Yvonne Yee Chin Yeap, Yuanyu Hu, Shirley Gek Kheng Seah, Sebastian Mauer-Stroh, Shanshan W Howland, Brendon John Hanson, Manuel Rosa-Calatrava, Aashish Manglik, Yifan Cheng, Charles S Craik, Cheng-I Wang
Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization. bioRxiv : the preprint server for biology (2020)
Michael Schoof, Bryan Faust, Reuben A Saunders, Smriti Sangwan, Veronica V Rezelj, Nicholas Hoppe, Morgane Boone, Christian B Billesbølle, Cristina Puchades, Caleigh M Azumaya, Huong T Kratochvil, Marcell Zimanyi, Ishan Deshpande, Jiahao Liang, Miles Sasha Dickinson, Henry C Nguyen, Cynthia M Chio, Gregory E Merz, Michael C Thompson, Devan Diwanji, Kaitlin Schaefer, Aditya A Anand, Niv Dobzinski, Beth Shoshanna Zha, Camille R Simoneau, Kristoffer E Leon, Kris M White, Un Seng Chio, Meghna Gupta, Mingliang Jin, Fei Li, Yanxin Liu, Kaihua Zhang, David Bulkley, Ming Sun, Amber M Smith, Alexandrea N Rizo, Frank R Moss, Axel F Brilot, Sergei Pourmal, Raphael Trenker, Thomas H Pospiech, Sayan Gupta, Benjamin Barsi-Rhyne, Vladislav Belyy, Andrew W Barile-Hill, Silke Nock, Yuwei Liu, Nevan J Krogan, Corie Y Ralston, Danielle L Swaney, Adolfo García-Sastre, Melanie M Ott, Marco Vignuzzi, null null, Peter Walter, Aashish Manglik
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike. Science (New York, N.Y.) 370 (6523) (2020)
David E Gordon, Joseph Hiatt, Mehdi Bouhaddou, Veronica V Rezelj, Svenja Ulferts, Hannes Braberg, Alexander S Jureka, Kirsten Obernier, Jeffrey Z Guo, Jyoti Batra, Robyn M Kaake, Andrew R Weckstein, Tristan W Owens, Meghna Gupta, Sergei Pourmal, Erron W Titus, Merve Cakir, Margaret Soucheray, Michael J McGregor, Zeynep Cakir, Gwendolyn M Jang, Matthew J O'Meara, Tia A Tummino, Ziyang Zhang, Helene Foussard, Ajda Rojc, Yuan Zhou, Dmitry Kuchenov, Ruth Hüttenhain, Jiewei Xu, Manon Eckhardt, Danielle L Swaney, Jacqueline M Fabius, Manisha Ummadi, Beril Tutuncuoglu, Ujjwal Rathore, Maya Modak, Paige Haas, Kelsey M Haas, Zun Zar Chi Naing, Ernst H Pulido, Ying Shi, Inigo Barrio-Hernandez, Danish Memon, Eirini Petsalaki, Alistair S Dunham, Miguel Correa Marrero, David Francis Burke, Cassandra Koh, Thomas Vallet, Jesus A Silvas, Caleigh M Azumaya, Christian B Billesbølle, Axel F Brilot, Melody G Campbell, Amy Diallo, Miles Sasha Dickinson, Devan Diwanji, Nadia Herrera, Nicholas Hoppe, Huong T Kratochvil, Yanxin Liu, Gregory E Merz, Michelle Moritz, Henry C Nguyen, Carlos A Nowotny, Cristina Puchades, Alexandrea N Rizo, Ursula Schulze-Gahmen, Amber M Smith, Ming Sun, Iris D Young, Jianhua Zhao, Daniel Asarnow, Justin T Biel, Alisa Bowen, Julian R Braxton, Jen Chen, Cynthia M Chio, Un Seng Chio, Ishan Deshpande, Loan Doan, Bryan Faust, Sebastian Flores, Mingliang Jin, Sun Kyung Kim, Victor L Lam, Fei Li, Junrui Li, Grant J Jensen, Yang Li, Xi Liu, Megan Lo, Kyle E Lopez, Arthur A Melo, Frank R Moss, Phuong Nguyen, Joana Paulino, Komal Ishwar Pawar, Jessica K Peters, Thomas H Pospiech, Maliheh Safari, Smriti Sangwan, Kaitlin Schaefer, Paul V Thomas, Aye C Thwin, Raphael Trenker, Eric Tse, Tsz Kin Martin Tsui, Feng Wang, Natalie Whitis, Zanlin Yu, Kaihua Zhang, Sunny Zhang, Fengbo Zhou, Daniel J Saltzberg, null null, Anthony J Hodder, Amber S Shun-Shion, Daniel M Williams, Kris M White, Romel Rosales, Thomas Kehrer, Lisa Miorin, Elena Moreno, Arvind H Patel, Suzannah J Rihn, Mir Mubashir Khalid, Albert Vallejo-Gracia, Parinaz Fozouni, Camille R Simoneau, Theodore L Roth, David Wu, Mohd Anisul Karim, Maya Ghoussaini, Ian Dunham, Francesco Berardi, Sebastian Weigang, Maxime Chazal, Jisoo Park, James P Logue, Marisa E McGrath, Stuart M Weston, Robert E Haupt, C James Hastie, Matthew Elliott, Fiona Brown, Kerry A Burness, Elaine Reid, Mark Dorward, Clare Johnson, Stuart G Wilkinson, Anna Geyer, Daniel M Giesel, Carla Baillie, Samantha Raggett, Hannah Leech, Rachel Toth, Nicola Goodman, Kathleen C Keough, Abigail L Lind, null null, Reyna J Klesh, Kafi R Hemphill, Jared Carlson-Stevermer, Jennifer Oki, Kevin Holden, Travis Maures, Katherine S Pollard, Andrej Sali, David A Agard, Yifan Cheng, Brian K Shoichet, Adam Frost, Natalia Jura, Tanja Kortemme, Aashish Manglik, Daniel R Southworth, Robert M Stroud, Dario R Alessi, Paul Davies, Matthew B Friemann, Trey Ideker, Carmen Abate, Nolwenn Jouvenet, Georg Kochs, Brian K Shoichet, Melanie M Ott, Massimo Palmarini, Kevan M Shokat, Adolfo García-Sastre, Jeremy A Rassen, Robert Grosse, Oren S Rosenberg, Kliment A Verba, Christopher F Basler, Marco Vignuzzi, Andrew A Peden, Pedro Beltrao, Nevan J Krogan
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.) 370 (6521) (2020)
Conor McMahon, Alexander S Baier, Roberta Pascolutti, Marcin Wegrecki, Sanduo Zheng, Janice X Ong, Sarah C Erlandson, Daniel Hilger, Søren G F Rasmussen, Aaron M Ring, Aashish Manglik, Andrew C Kruse
Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nature structural & molecular biology 25 (3) (2018)