Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma.

Hongxia LiMeiying ZhangEnqiang LinghuFuyou ZhouJames G HermanLiming HuMingzhou Guo

Published in: Clinical epigenetics (2018)

The promoter region of TMEM176A is frequently methylated in human HCC, and the expression of TMEM176A is regulated by promoter region methylation. Methylation of the TMEM176A promoter may serve as a diagnostic and prognostic marker in HCC. TMEM176A suppresses HCC growth by inhibiting the ERK signaling pathway.

Keyphrases

signaling pathway
dna methylation
pi k akt
gene expression
endothelial cells
genome wide
transcription factor
induced apoptosis
epithelial mesenchymal transition
induced pluripotent stem cells
poor prognosis
cell proliferation
pluripotent stem cells
oxidative stress