Leonurine Promotes Cisplatin Sensitivity in Human Cervical Cancer Cells Through Increasing Apoptosis and Inhibiting Drug-Resistant Proteins.

Min Lin Chunyu Pan Wenbin Xu Jingwei Li Xueqiong Zhu

Published in: Drug design, development and therapy (2020)

Leonurine and cisplatin have synergistic antitumorigenic effects on cervical cancer. Combination with leonurine may serve as a novel strategy for enhancing cisplatin sensitivity via the inhibition of the expression of MRP1 and P-Gp.

Keyphrases

drug resistant
multidrug resistant
acinetobacter baumannii
endothelial cells
poor prognosis
oxidative stress
cell death
endoplasmic reticulum stress
cell cycle arrest
pseudomonas aeruginosa
pluripotent stem cells
cystic fibrosis
long non coding rna
drug delivery
binding protein