MicroRNA Expression in Patients with Coronary Artery Disease and Hypertension-A Systematic Review.
Bartosz KondrackiMateusz KłodaAnna Jusiak-KłodaAdrianna KondrackaJakub WacińskiPiotr WacińskiPublished in: International journal of molecular sciences (2024)
Coronary artery disease (CAD) and hypertension significantly contribute to cardiovascular morbidity and mortality. MicroRNAs (miRNAs) have recently emerged as promising biomarkers and therapeutic targets for these conditions. This systematic review conducts a thorough analysis of the literature, with a specific focus on investigating miRNA expression patterns in patients with CAD and hypertension. This review encompasses an unspecified number of eligible studies that employed a variety of patient demographics and research methodologies, resulting in diverse miRNA expression profiles. This review highlights the complex involvement of miRNAs in CAD and hypertension and the potential for advances in diagnostic and therapeutic strategies. Future research endeavors are imperative to validate these findings and elucidate the precise roles of miRNAs in disease progression, offering promising avenues for innovative diagnostic tools and targeted interventions.
Keyphrases
- coronary artery disease
- blood pressure
- systematic review
- poor prognosis
- cardiovascular events
- coronary artery bypass grafting
- case report
- cardiovascular disease
- type diabetes
- cancer therapy
- randomized controlled trial
- acute coronary syndrome
- long non coding rna
- heart failure
- binding protein
- atrial fibrillation
- transcatheter aortic valve replacement
- aortic valve
- case control
- left ventricular
- aortic stenosis