miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients.

Diya SunZuoyou DingLei ShenFan YangJun HanGuohao Wu

Published in: Lipids in health and disease (2021)

The expression of miR-410-3p was higher in subcutaneous adipose tissues and serum exosomes of CAC patients, which significantly inhibits adipogenesis and lipid accumulation. The study shows that miR-410-3p could downregulate IRS-1 and downstream adipose differentiation factors including C/EBP-a and PPAR-γ by targeting 3' noncoding region.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
insulin resistance
chronic kidney disease
adipose tissue
peritoneal dialysis
gene expression
stem cells
poor prognosis
fatty acid
patient reported outcomes
metabolic syndrome
skeletal muscle
binding protein