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miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients.

Diya SunZuoyou DingLei ShenFan YangJun HanGuohao Wu
Published in: Lipids in health and disease (2021)
The expression of miR-410-3p was higher in subcutaneous adipose tissues and serum exosomes of CAC patients, which significantly inhibits adipogenesis and lipid accumulation. The study shows that miR-410-3p could downregulate IRS-1 and downstream adipose differentiation factors including C/EBP-a and PPAR-γ by targeting 3' noncoding region.
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