Dissecting the potential mechanism of antihypertensive effects of RVPSL on spontaneously hypertensive rats via widely targeted kidney metabolomics.
Zhipeng YuLi WangSijia WuWenzhu ZhaoPublished in: Journal of the science of food and agriculture (2022)
The study suggested that RVPSL may exert antihypertensive effects through upregulation of O-phospho-l-serine, 3-hydroxybutyrate and 15-oxoETE, and downregulation of tyramine, citric acid, O-acetyl-l-serine, 3,3',5-triiodo-l-thyronine and dopaquinone. The antihypertensive effects of RVPSL may be related to carbon metabolism, thyroid hormone signaling pathway, tyrosine metabolism and arachidonic acid metabolism. RVPSL exhibited a potent antihypertensive effect, and the antihypertensive effects were associated with inhibition of vascular smooth muscle cell proliferation, vascular remodeling, vascular endothelium dysfunction, restoring reactive oxygen species, oxidative stress, inflammation and immune reaction. © 2022 Society of Chemical Industry.
Keyphrases
- blood pressure
- oxidative stress
- cell proliferation
- signaling pathway
- hypertensive patients
- smooth muscle
- reactive oxygen species
- pi k akt
- mass spectrometry
- induced apoptosis
- dna damage
- nitric oxide
- poor prognosis
- ischemia reperfusion injury
- protein kinase
- anti inflammatory
- climate change
- endoplasmic reticulum stress
- heat shock protein
- drug induced