Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids.
Yifei MiaoCheng TanNicole M PekZhiyun YuKentaro IwasawaDaniel O KecheleNambirajan SundaramVictor Pastrana-GomezKeishi KishimotoMin-Chi YangCheng JiangJason TchieuJeffrey A WhitsettKyle W McCrackenRobbert J RottierDarrell N KottonMichael A HelmrathJames M WellsTakanori TakebeAaron M ZornYa-Wen ChenMinzhe GuoMingxia GuPublished in: bioRxiv : the preprint server for biology (2024)
BMP signaling fine-tunes the co-differentiation of mesoderm and endoderm.The cellular composition in multilineage organoids resembles that of human fetal organs.Mesenchyme and endothelium co-developed within the organoids adopt organ-specific characteristics.Multilineage organoids recapitulate abnormal endothelial-epithelial crosstalk in FOXF1-associated disorders.