Combined PARP and HSP90 inhibition: preclinical and Phase 1 evaluation in patients with advanced solid tumours.

Panagiotis A KonstantinopoulosSu-Chun ChengJeffrey G SupkoMadeline PolakAndrea E Wahner-HendricksonS Percy IvyBrittany BowesHannah SawyerPatrice BasadaMartin HayesJennifer CurtisNeil HorowitzAlexi A WrightSusana M CamposElena V IvanovaCloud P PaweletzSangeetha PalakurthiJoyce F LiuAlan D' Andrea Prafulla C GokhaleDipanjan ChowdhuryUrsula A MatulonisGeoffrey I Shapiro

Published in: British journal of cancer (2021)

Combining onalespib and olaparib was feasible and demonstrated preliminary evidence of anti-tumour activity.

Keyphrases

heat shock protein
dna damage
dna repair
heat stress
heat shock
cell therapy
stem cells
oxidative stress
mesenchymal stem cells