Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis.
Trang Hong NguyenIlona TurekTerri Meehan-AndrewsAnita ZachariasHelen R IrvingPublished in: PloS one (2020)
The review identifies significant effects of IRAK3 on decreasing NF-κB DNA binding activity in cell lines, TNF-α protein level at intermediate time intervals (4h-15h) in cell lines or at long term intervals (16h-48h) in mouse primary cells following one-challenge. The patterns of TNF-α protein expression in human cell lines and human primary cells in response to one-challenge are more similar than in mouse primary cells. Meta-analyses confirm a negative correlation between IRAK3 and inflammatory cytokine (IL-6 and TNF-α) expression after two-challenges.
Keyphrases
- induced apoptosis
- cell cycle arrest
- rheumatoid arthritis
- signaling pathway
- dna binding
- endothelial cells
- poor prognosis
- oxidative stress
- systematic review
- endoplasmic reticulum stress
- binding protein
- meta analyses
- transcription factor
- genome wide
- gene expression
- small molecule
- induced pluripotent stem cells
- pi k akt
- cell proliferation
- long non coding rna
- pluripotent stem cells
- toll like receptor