UK Transcatheter Aortic Valve Implantation trial - time to differentiate "non-inferiority" from "equivalence"?
Pradeep NarayanPublished in: Indian journal of thoracic and cardiovascular surgery (2022)
The UK Transcatheter Aortic Valve Implantation (UK-TAVI) trial has compared transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) in patients above the age of 70 years with moderate operative risk. The primary outcome was 1-year all-cause mortality. This was a non-inferiority trial that concluded that TAVI in this cohort was non-inferior to SAVR. This appraisal reports the main findings of the study and discusses the strengths and weaknesses of the trial.
Keyphrases
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- aortic valve
- ejection fraction
- phase iii
- study protocol
- phase ii
- clinical trial
- transcatheter aortic valve replacement
- randomized controlled trial
- end stage renal disease
- open label
- cross sectional
- left ventricular
- chronic kidney disease
- newly diagnosed
- heart failure
- emergency department
- high intensity
- electronic health record
- adverse drug