Bacterial Butyrate in Parkinson's Disease Is Linked to Epigenetic Changes and Depressive Symptoms.

Aoji Xie Elizabeth Ensink Peipei Li Juozas GordevičiusLee L MarshallSonia George John Andrew Pospisilik Velma T E Aho Madelyn C Houser Pedro A B PereiraKnut RudiLars Paulin Malú Gámez Tansey Petri AuvinenPatrik BrundinLena BrundinViviane LabrieFilip Scheperjans

Published in: Movement disorders : official journal of the Movement Disorder Society (2022)

Decreased levels of bacterially produced butyrate are related to epigenetic changes in leucocytes and neurons from PD patients and to the severity of their depressive symptoms. PD shares common butyrate-dependent epigenetic changes with certain GI and psychiatric disorders, which could be relevant for their epidemiological relation. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

depressive symptoms
dna methylation
gene expression
end stage renal disease
ejection fraction
chronic kidney disease
social support
newly diagnosed
prognostic factors
spinal cord
peritoneal dialysis
randomized controlled trial
sleep quality
physical activity
patient reported outcomes