miR-450a-2-3p targets ERK(1/2) to ameliorate ISO-induced cardiac fibrosis in mice.

Langsha LiuFanyan Luo

Published in: Genes & nutrition (2024)

Our study reveals the mechanistic connection between ISO-induced myocardial fibrosis and the miR-450a-2-3p/ERK(1/2) signaling pathway, highlighting its role in the development of cardiac fibrosis. Modulating miR-450a-2-3p expression and inhibiting ERK(1/2) activation are promising approaches for therapeutic intervention in patients with AF.

Keyphrases

signaling pathway
pi k akt
left ventricular
epithelial mesenchymal transition
induced apoptosis
high glucose
cell proliferation
randomized controlled trial
poor prognosis
liver fibrosis
drug induced
heart failure
oxidative stress
insulin resistance
long non coding rna
metabolic syndrome
high fat diet induced