Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice.

Allison L FisherSydney Phillips Chia-Yu Wang Joao A Paulo Xia XiaoGillian A MoschettaAdhvaith SridharJoseph D ManciasJodie L Babitt

Published in: Blood (2024)

Iron-mediated induction of BMP6 expression by liver endothelial cells is essential for iron homeostasis regulation. We utilized multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for ZIP8 in regulating BMP6 expression under high-iron conditions.

Keyphrases

endothelial cells
poor prognosis
mesenchymal stem cells
iron deficiency
bone regeneration
type diabetes
metabolic syndrome
long non coding rna
adipose tissue
copy number
vascular endothelial growth factor