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ToxNav germline genetic testing and PROMinet digital mobile application toxicity monitoring: Results of a prospective single-center clinical utility study-PRECISE study.

Lennard Y W LeeThomas StarkeyShivan SivakumarSusan FotheringhamGuy MozolowskiVanessa ShearwoodClaire PallesPhilip CamilleriDavid N ChurchRachel KerrDavid Kerr
Published in: Cancer medicine (2019)
The PRECISE clinical trial demonstrated that a germline DNA sequencing-based test can provide clinically relevant information to alter clinicians' fluoropyrimidine prescription. The study also obtained high volume, high granularity patient-reported toxicity data that might allow the improvement and personalization of chemotherapy management.
Keyphrases
  • clinical trial
  • squamous cell carcinoma
  • randomized controlled trial
  • palliative care
  • machine learning
  • healthcare
  • dna repair
  • study protocol
  • dna damage
  • health information
  • locally advanced
  • double blind