Molecular basis for plasma membrane recruitment of PI4KA by EFR3.
Sushant SureshAlexandria L ShawJoshua G PembertonMackenzie K ScottNoah J HarrisMatthew Ah ParsonMeredith L JenkinsPoojah RohillaAlejandro Alvarez-PratsTamas BallaCalvin K YipJohn E BurkePublished in: bioRxiv : the preprint server for biology (2024)
The cryo-EM structure of the C-terminus of EFR3A bound to the PI4KA complex reveals the molecular mechanism underlying PI4KA membrane localisation, and provides novel insight into PI4KA regulation and its involvement in human disease.
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