John E Burke (John Burke)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 71

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

bioRxiv : the preprint server for biology

eLife

University of Victoria

University of San Diego (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Victoria Mar 01 2014

Canada

Assistant Professor :: Biochemistry and Microbiology

Education History

University of San Diego

United States

PHD :: Chemistry and Biochemistry

University of Califronia Berkeley

United States

BSC :: Chemistry

Publications

Sushant Suresh, Alexandria L Shaw, Joshua G Pemberton, Mackenzie K Scott, Noah J Harris, Matthew Ah Parson, Meredith L Jenkins, Poojah Rohilla, null Alejandro-Alvarez-Prats, Tamas Balla, Calvin K Yip, John E Burke
Molecular basis for plasma membrane recruitment of PI4KA by EFR3. bioRxiv : the preprint server for biology (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Sushant Suresh, Alexandria L Shaw, Joshua G Pemberton, Mackenzie K Scott, Noah J Harris, Matthew Ah Parson, Meredith L Jenkins, Pooja Rohilla, Alejandro Alvarez-Prats, Tamas Balla, Calvin K Yip, John E Burke
Molecular basis for plasma membrane recruitment of PI4KA by EFR3. bioRxiv : the preprint server for biology (2024)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages. eLife 12 (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Sushant Suresh, Alexandria L Shaw, Joshua G Pemberton, Mackenzie K Scott, Noah J Harris, Matthew Ah Parson, Meredith L Jenkins, Poojah Rohilla, Alejandro Alvarez Prats, Tamas Balla, Calvin K Yip, John E Burke
Molecular basis for plasma membrane recruitment of PI4KA by EFR3. bioRxiv : the preprint server for biology (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages. eLife 12 (2024)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages. eLife 12 (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages. eLife 12 (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin L Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America 121 (3) (2024)
Sushant Suresh, Alexandria L Shaw, Joshua G Pemberton, Mackenzie K Scott, Noah J Harris, Matthew Ah Parson, Meredith L Jenkins, Poojah Rohilla, Alejandro Alvarez Prats, Tamas Balla, Calvin K Yip, John E Burke
Molecular basis for plasma membrane recruitment of PI4KA by EFR3. bioRxiv : the preprint server for biology (2024)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6-specific nanobody restricts M. tuberculosis growth in macrophages. eLife 12 (2024)
Sushant Suresh, Alexandria L Shaw, Joshua G Pemberton, Mackenzie K Scott, Noah J Harris, Matthew Ah Parson, Meredith L Jenkins, Poojah Rohilla, Alejandro Alvarez-Prats, Tamas Balla, Calvin K Yip, John E Burke
Molecular basis for plasma membrane recruitment of PI4KA by EFR3. bioRxiv : the preprint server for biology (2024)
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew A H Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheekey, Scott D Hansen, Calvin K Yip, John E Burke
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain. bioRxiv : the preprint server for biology (2023)
Meredith L Jenkins, Harish Ranga-Prasad, Matthew A H Parson, Noah J Harris, Manoj K Rathinaswamy, John E Burke
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus. Nature communications 14 (1) (2023)
Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A Eisler, Tanja Hägele, Matthew A H Parson, John E Burke, Angelika Hausser, Thomas A Leonard
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis . Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Meredith L Jenkins, Harish Ranga-Prasad, Matthew A H Parson, Noah J Harris, Manoj K Rathinaswamy, John E Burke
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus. Nature communications 14 (1) (2023)
Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A Eisler, Tanja Hägele, Matthew A H Parson, John E Burke, Angelika Hausser, Thomas A Leonard
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis . Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A Eisler, Tanja Hägele, Matthew A H Parson, John E Burke, Angelika Hausser, Thomas A Leonard
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis . Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A Eisler, Tanja Hägele, Matthew A H Parson, John E Burke, Angelika Hausser, Thomas A Leonard
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis . Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew A H Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheekey, Scott D Hansen, Calvin K Yip, John E Burke
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain. bioRxiv : the preprint server for biology (2023)
Meredith L Jenkins, Harish Ranga-Prasad, Matthew A H Parson, Noah J Harris, Manoj K Rathinaswamy, John E Burke
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus. Nature communications 14 (1) (2023)
Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A Eisler, Tanja Hägele, Matthew A H Parson, John E Burke, Angelika Hausser, Thomas A Leonard
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis . Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Yong Mi Choi, Dalila Ajjaji, Kaelin D Fleming, Peter P Borbat, Meredith L Jenkins, Brandon E Moeller, Shaveen Fernando, Surita R Bhatia, Jack H Freed, John E Burke, Abdou Rachid Thiam, Michael V Airola
Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation. Nature communications 14 (1) (2023)
Meredith L Jenkins, Harish Ranga-Prasad, Matthew A H Parson, Noah J Harris, Manoj K Rathinaswamy, John E Burke
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus. Nature communications 14 (1) (2023)
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew A H Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheeky, Scott D Hansen, Calvin K Yip, John E Burke
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain. eLife 12 (2023)
Meredith L Jenkins, Harish Ranga-Prasad, Matthew A H Parson, Noah J Harris, Manoj K Rathinaswamy, John E Burke
Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus. Nature communications 14 (1) (2023)
Neng Wan, Zhouping Hong, Matthew A H Parson, Justin Korfhage, John E Burke, Thomas J Melia, Karin M Reinisch
Spartin-mediated lipid transfer facilitates lipid droplet turnover. bioRxiv : the preprint server for biology (2023)
Ronja Reinhardt, Kai Hirzel, Gisela Link, Stephan A Eisler, Tanja Hägele, Matthew A H Parson, John E Burke, Angelika Hausser, Thomas A Leonard
PKD autoinhibition in trans regulates activation loop autophosphorylation in cis . Proceedings of the National Academy of Sciences of the United States of America 120 (7) (2023)
Timothy A Bates, Mila Trank-Greene, Xammy Huu Nguyenla, Aidan Anastas, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew A H Parson, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
ESAT-6 undergoes self-association at phagosomal pH and an ESAT-6 specific nanobody restricts M. tuberculosis growth in macrophages. bioRxiv : the preprint server for biology (2023)
Noah J Harris, Meredith L Jenkins, Sung-Eun Nam, Manoj K Rathinaswamy, Matthew A H Parson, Harish Ranga-Prasad, Udit Dalwadi, Brandon E Moeller, Eleanor Sheekey, Scott D Hansen, Calvin K Yip, John E Burke
Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain. bioRxiv : the preprint server for biology (2023)
Matthew A H Parson, Meredith L Jenkins, John E Burke
Investigating how intrinsically disordered regions contribute to protein function using HDX-MS. Biochemical Society transactions (2022)
Jacob A McPhail, John E Burke
Molecular mechanisms of PI4K regulation and their involvement in viral replication. Traffic (Copenhagen, Denmark) (2022)
Aleksandra Levina, Kaelin D Fleming, John E Burke, Thomas A Leonard
Activation of the essential kinase PDK1 by phosphoinositide-driven trans-autophosphorylation. Nature communications 13 (1) (2022)
Edhriz Siraliev-Perez, Jordan T B Stariha, Reece M Hoffmann, Brenda R S Temple, Qisheng Zhang, Nicole Hajicek, Meredith L Jenkins, John E Burke, John Sondek
Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes. eLife 11 (2022)
John E Burke, Joanna Triscott, Brooke M Emerling, Gerald R V Hammond
Beyond PI3Ks: targeting phosphoinositide kinases in disease. Nature reviews. Drug discovery (2022)
Chiara Borsari, Erhan Keles, Jacob A McPhail, Alexander Schaefer, Rohitha Sriramaratnam, Wojciech Goch, Thorsten Schaefer, Martina De Pascale, Wojciech Bal, Matthias Gstaiger, John E Burke, Matthias P Wymann
Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα. Journal of the American Chemical Society 144 (14) (2022)
Bart Vanhaesebroeck, John E Burke, Ralitsa R Madsen
Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation. Cancer discovery 12 (1) (2022)
Manoj K Rathinaswamy, Udit Dalwadi, Kaelin D Fleming, Carson Adams, Jordan T B Stariha, Els Pardon, Minkyung Baek, Oscar Vadas, Frank Dimaio, Jan Steyaert, Scott D Hansen, Calvin K Yip, John E Burke
Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation. Science advances 7 (35) (2021)
Idil Ulengin-Talkish, Matthew A H Parson, Meredith L Jenkins, Jagoree Roy, Alexis Z L Shih, Nicole St-Denis, Gergő Gulyás, Tamas Balla, Anne-Claude Gingras, Péter Várnai, Elizabeth Conibear, John E Burke, Martha S Cyert
Palmitoylation targets the calcineurin phosphatase to the phosphatidylinositol 4-kinase complex at the plasma membrane. Nature communications 12 (1) (2021)
Minkyung Baek, Frank Dimaio, David Baker, Justas Dauparas, Sergey Ovchinnikov, Gyu Rie Lee, Jue Wang, Nick V Grishin, Lisa N Kinch, R Dustin Schaeffer, Claudia Millán, Hahnbeom Park, Carson Adams, Caleb R Glassman, Andy DeGiovanni, Jose Henrique Pereira, Andria V Rodrigues, Alberdina A van Dijk, Ana C Ebrecht, Diederik Johannes Opperman, Theo Sagmeister, Christoph Buhlheller, Tea Pavkov-Keller, Manoj K Rathinaswamy, Udit Dalwadi, Calvin K Yip, John E Burke, K Christopher Garcia, Nick V Grishin, Paul D Adams, Randy J Read, Julien S Baker
Accurate prediction of protein structures and interactions using a three-track neural network. Science (New York, N.Y.) 373 (6557) (2021)
Linda Truebestein, Harald Hornegger, Dorothea Anrather, Markus Hartl, Kaelin D Fleming, Jordan T B Stariha, Els Pardon, Jan Steyaert, John E Burke, Thomas A Leonard
Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
Yu Seby Chen, Guennadi Kozlov, Brandon E Moeller, Ahmed Rohaim, Rayan Fakih, Benoı T Roux, John E Burke, Kalle Gehring
Crystal structure of an archaeal CorB magnesium transporter. Nature communications 12 (1) (2021)
Weijing Gu, Shujuan Gao, Huan Wang, Kaelin D Fleming, Reece M Hoffmann, Jong Won Yang, Nimi M Patel, Yong Mi Choi, John E Burke, Karen Reue, Michael V Airola
The middle lipin domain adopts a membrane-binding dimeric protein fold. Nature communications 12 (1) (2021)
Nivea Pereira de Sa, Adam Taouil, Jinwoo Kim, Timothy Clement, Reece M Hoffmann, John E Burke, Robert C Rizzo, Iwao Ojima, Maurizio Del Poeta, Michael V Airola
Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents. Nature communications 12 (1) (2021)
Manoj K Rathinaswamy, Zied Gaieb, Kaelin D Fleming, Chiara Borsari, Noah J Harris, Brandon E Moeller, Matthias P Wymann, Rommie E Amaro, John E Burke
Disease-related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveal a path to selective inhibitors. eLife 10 (2021)
Stephen Fienberg, Charles J Eyermann, Lauren B Arendse, Gregory S Basarab, Jacob A McPhail, John E Burke, Kelly Chibale
Structural Basis for Inhibitor Potency and Selectivity of Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors. ACS infectious diseases 6 (11) (2020)
Joseph M Dobbs, Meredith L Jenkins, John E Burke
Escherichia coli and Sf9 Contaminant Databases to Increase Efficiency of Tandem Mass Spectrometry Peptide Identification in Structural Mass Spectrometry Experiments. Journal of the American Society for Mass Spectrometry 31 (10) (2020)
Valerie I Khayyo, Reece M Hoffmann, Huan Wang, Justin A Bell, John E Burke, Karen Reue, Michael V Airola
Publisher Correction: Crystal structure of a lipin/Pah phosphatidic acid phosphatase. Nature communications 11 (1) (2020)
Valerie I Khayyo, Reece M Hoffmann, Huan Wang, Justin A Bell, John E Burke, Karen Reue, Michael V Airola
Crystal structure of a lipin/Pah phosphatidic acid phosphatase. Nature communications 11 (1) (2020)
Meredith L Jenkins, Noah J Harris, Udit Dalwadi, Kaelin D Fleming, Daniel S Ziemianowicz, Atefeh Rafiei, Emily M Martin, David C Schriemer, Calvin K Yip, John E Burke
The substrate specificity of the human TRAPPII complex's Rab-guanine nucleotide exchange factor activity. Communications biology 3 (1) (2020)
Denise Rageot, Thomas Bohnacker, Erhan Keles, Jacob A McPhail, Reece M Hoffmann, Anna Melone, Chiara Borsari, Rohitha Sriramaratnam, Alexander M Sele, Florent Beaufils, Paul Hebeisen, Doriano Fabbro, Petra Hillmann, John E Burke, Matthias P Wymann
(S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. Journal of medicinal chemistry 62 (13) (2019)
Jacob A McPhail, Heyrhyoung Lyoo, Joshua G Pemberton, Reece M Hoffmann, Wendy van Elst, Jeroen R P M Strating, Meredith L Jenkins, Jordan T B Stariha, Cameron J Powell, Martin J Boulanger, Tamas Balla, Frank J M van Kuppeveld, John E Burke
Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication. EMBO reports 21 (2) (2019)
John E Burke
Dynamic structural biology at the protein membrane interface. The Journal of biological chemistry 294 (11) (2019)
Prajna Shanbhogue, Reece M Hoffmann, Michael V Airola, Rohan Maini, David J Hamelin, Miguel Garcia-Diaz, John E Burke, Yusuf A Hannun
The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. The Journal of biological chemistry 294 (18) (2019)
Glenn Robert Masson, John E Burke, Natalie G Ahn, Ganesh S Anand, Christoph Borchers, Sébastien Brier, George M Bou-Assaf, John R Engen, S Walter Englander, Johan Faber, Rachel Garlish, Patrick R Griffin, Michael L Gross, Miklos Guttman, Yoshitomo Hamuro, Albert J R Heck, Damian Houde, Roxana E Iacob, Thomas J D Jørgensen, Igor A Kaltashov, Judith P Klinman, Lars Konermann, Petr Man, Leland Mayne, Bruce D Pascal, Dana Reichmann, Mark Skehel, Joost Snijder, Timothy S Strutzenberg, Eric S Underbakke, Cornelia Wagner, Thomas E Wales, Benjamin T Walters, David D Weis, Derek J Wilson, Patrick L Wintrode, Zhongqi Zhang, Jie Zheng, David C Schriemer, Kasper Dyrberg Rand
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments. Nature methods 16 (7) (2019)
Samantha D Heitz, David J Hamelin, Reece M Hoffmann, Nili Greenberg, Gilbert Salloum, Zahra Erami, Bassem D Khalil, Aliaksei Shymanets, Elizabeth A Steidle, Grace Q Gong, Bernd Nürnberg, John E Burke, Jack U Flanagan, Anne R Bresnick, Jonathan M Backer
A single discrete Rab5-binding site in phosphoinositide 3-kinase β is required for tumor cell invasion. The Journal of biological chemistry 294 (12) (2019)
Chimno I Nnadi, Meredith L Jenkins, Daniel R Gentile, Leslie A Bateman, Daniel Zaidman, Trent E Balius, Daniel K Nomura, John E Burke, Kevan M Shokat, Nir London
Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange. Journal of chemical information and modeling 58 (2) (2018)
Cameron J Powell, Raghavendran Ramaswamy, Anne Kelsen, David J Hamelin, David M Warshaw, Jürgen Bosch, John E Burke, Gary E Ward, Martin J Boulanger
Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America 115 (45) (2018)
Meredith L Jenkins, Jean Piero Margaria, Jordan T B Stariha, Reece M Hoffmann, Jacob A McPhail, David J Hamelin, Martin J Boulanger, Emilio Hirsch, John E Burke
Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5. Nature communications 9 (1) (2018)
Denise Rageot, Thomas Bohnacker, Anna Melone, Jean-Baptiste Langlois, Chiara Borsari, Petra Hillmann, Alexander M Sele, Florent Beaufils, Marketa Zvelebil, Paul Hebeisen, Wolfgang Löscher, John E Burke, Doriano Fabbro, Matthias P Wymann
Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders. Journal of medicinal chemistry 61 (22) (2018)
Iva Lučić, Manoj K Rathinaswamy, Linda Truebestein, David J Hamelin, John E Burke, Thomas A Leonard
Conformational sampling of membranes by Akt controls its activation and inactivation. Proceedings of the National Academy of Sciences of the United States of America 115 (17) (2018)
Gillian L Dornan, Braden D Siempelkamp, Meredith L Jenkins, Oscar Vadas, Carrie L Lucas, John E Burke
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1. Proceedings of the National Academy of Sciences of the United States of America 114 (8) (2017)
Glenn Robert Masson, Meredith L Jenkins, John E Burke
An overview of hydrogen deuterium exchange mass spectrometry (HDX-MS) in drug discovery. Expert opinion on drug discovery 12 (10) (2017)
Lynn M McGregor, Meredith L Jenkins, Caitlin Kerwin, John E Burke, Kevan M Shokat
Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes. Biochemistry 56 (25) (2017)
Thomas Bohnacker, Andrea E Prota, Florent Beaufils, John E Burke, Anna Melone, Alison J Inglis, Denise Rageot, Alexander M Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L Williams, Michel O Steinmetz, Matthias P Wymann
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention. Nature communications 8 (2017)

John E Burke.css-eqlu8i{font-size:small;padding-left:4px;} (John Burke)

Publication Activity (10 Years)

Top Topics

Top Venues

John E Burke (John Burke)