Combination Therapy of Pulmonary Arterial Hypertension with Vardenafil and Macitentan Assessed in a Human Ex Vivo Model.

Markus HoenickaSvitlana GolovchenkoLeonie EnglertMirjam SpaethLevani ShoshiashviliChristian GroßerHans-Stefan HofmannMichael Ried

Published in: Cardiovascular drugs and therapy (2020)

These data suggest that vasodilator effects of macitentan and vardenafil combined may surpass monotherapy in vivo if drug doses are adjusted properly. Vasodilation by the longer-acting metabolite ACT-132577 was not further enhanced by vardenafil.

Keyphrases

pulmonary arterial hypertension
combination therapy
pulmonary artery
pulmonary hypertension
endothelial cells
electronic health record
induced pluripotent stem cells
pluripotent stem cells
randomized controlled trial
coronary artery
data analysis
open label