The anti-inflammatory effect of high-density lipoprotein is blunted by delivery of altered microRNA cargo in rheumatoid arthritis patients.

Qiong WuQuanhu ShengDanielle MichellMarisol Ramirez-SolanoOlivia PoseyAnastasiia PhothisaneShahensha ShaikKasey C VickersMichelle J Ormseth

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

HDL-miR-1246 was increased in RA versus control subjects and delivery of miR-1246 to macrophages increased IL-6 expression by targeting DUSP3. The altered HDL-miRNA cargo in RA blunted HDL's anti-inflammatory effect.

Keyphrases

anti inflammatory
rheumatoid arthritis patients
high density
disease activity
long non coding rna
cell proliferation
rheumatoid arthritis
poor prognosis
long noncoding rna
systemic lupus erythematosus
ankylosing spondylitis
interstitial lung disease
idiopathic pulmonary fibrosis