Functional analysis of bovine interleukin-10 receptor alpha in response to Mycobacterium avium subsp. paratuberculosis lysate using CRISPR/Cas9.
Sanjay MallikarjunappaUmesh K ShandilyaAnkita SharmaKristen LamersNathalie BissonnetteNiel A KarrowKieran G MeadePublished in: BMC genetics (2020)
The findings of this study illustrate the broad and significant effects of knocking out the IL10RA gene in enhancing pro-inflammatory cytokine expression and further support the immunoregulatory role of IL10RA in eliciting an anti-inflammatory response as well as its potential functional involvement during the immune response associated with JD.
Keyphrases
- inflammatory response
- crispr cas
- immune response
- rheumatoid arthritis
- genome editing
- poor prognosis
- disease activity
- mycobacterium tuberculosis
- toll like receptor
- lipopolysaccharide induced
- binding protein
- genome wide
- dendritic cells
- systemic lupus erythematosus
- transcription factor
- long non coding rna
- idiopathic pulmonary fibrosis
- genome wide analysis