Cas9 Mediated Correction of β-catenin Mutation and Restoring the Expression of Protein Phosphorylation in Colon Cancer HCT-116 Cells Decrease Cell Proliferation in vitro and Hamper Tumor Growth in Mice in vivo.
Yanlan LiXiangning LiJiayao QuDixian LuoZheng HuPublished in: OncoTargets and therapy (2020)
The data of this study documented that correction of the driven mutation by the combination of CRISPR/Cas9 and ssODN could greatly remedy the biological behavior of the cancer cell line, suggesting a potential application of this strategy in gene therapy of cancer.
Keyphrases
- amino acid
- crispr cas
- cell proliferation
- gene therapy
- papillary thyroid
- genome editing
- squamous cell
- cell cycle arrest
- poor prognosis
- induced apoptosis
- lymph node metastasis
- epithelial mesenchymal transition
- pi k akt
- oxidative stress
- childhood cancer
- long non coding rna
- young adults
- small molecule
- binding protein
- protein kinase
- data analysis