Membrane-type 1 matrix metalloproteinase as predictor of survival and candidate therapeutic target in Ewing sarcoma.

Marcus J BrookesElizabeth A RoundhillLee JeysMichael ParrySusan A BurchillKenneth S Rankin

Published in: Pediatric blood & cancer (2022)

MT1-MMP is expressed by ES cells, including ES-CSCs, making it a candidate therapeutic target. The level of MT1-MMP expression at diagnosis may be considered as a prognostic biomarker if validated by retrospective analysis of a larger cohort of clinical trial samples.

Keyphrases

clinical trial
induced apoptosis
poor prognosis
cell cycle arrest
cell migration
cross sectional
endoplasmic reticulum stress
phase ii
study protocol
oxidative stress
double blind
cell proliferation
cancer stem cells
phase iii