ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.

Kirsten M DickersonChunxu QuQingsong GaoIlaria Iacobucci Zhaohui GuHiroki YoshiharaEmily A BackhausYunchao ChangLaura J JankeBei-Si XuGang WuEvangelia K PapachristouClive S D'SantosKathryn G Roberts Charles G Mullighan

Published in: Blood cancer discovery (2022)

Expression of ZNF384 FO early in hematopoiesis results in binding and deregulation of key hematopoietic regulators, skewing of hematopoiesis, and priming for leukemic transformation. These results reveal the interplay between cell of origin and expression of ZNF384 FO to mediate lineage ambiguity and leukemia development. This article is highlighted in the In This Issue feature, p. 171.

Keyphrases

single cell
poor prognosis
bone marrow
acute myeloid leukemia
machine learning
cell therapy
stem cells
gene expression
dna binding