Transgenic expression of human leukocyte antigen-E attenuates GalKO.hCD46 porcine lung xenograft injury.

Christopher T LairdLars BurdorfBeth M FrenchNatalia KubickiXiangfei ChengGheorghe BraileanuWenji SunNatalie A O'NeillArielle CimenoDawn ParsellEdward SoAndrea BährNikolai KlymiukCarol J PhelpsDavid AyaresAgnes M AzimzadehRichard N Pierson

Published in: Xenotransplantation (2017)

We conclude human NK cell activation contributes significantly to GalTKO.hCD46 pig endothelial injury and lung inflammation and show that expression of HLA-E is associated with physiologically meaningful protection of GalTKO.hCD46 cells and organs exposed to human blood.

Keyphrases

endothelial cells
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
oxidative stress
induced apoptosis
nk cells
signaling pathway
binding protein