Increased Expression of Interleukin-13 Receptor in Ileum Associated With Nonresponse to Adalimumab in Ileal Crohn's Disease.
Emily Chu Lee WongArif YusufJagoda PokryszkaParambir S DulaiJean Frederic ColombelJohn K MarshallWalter ReinischNeeraj NarulaPublished in: Inflammatory bowel diseases (2022)
Ileal histologic disease activity and IHC activation markers of chronic mucosal inflammation were not associated with 1-year ER. However, strong staining for IL-13 receptor in the ileum was associated with reduced odds of 1-year ER using adalimumab. Mucosal cellular disease profiles might pose an opportunity to guide treatment of CD.