Heterogeneity of axial spondyloarthritis: genetics, sex and structural damage matter.

Zhixiu Li Sjef M van der Linden Muhammad Asim KhanHeinz BaumbergerHermine van ZandwijkMohammad Kazim Khan Peter M Villiger Matthew A Brown

Published in: RMD open (2022)

Women clinically diagnosed with axSpA but without radiographic sacroiliitis as a group have a disease that is distinct from AS by the modified New York criteria overall and from nr-axSpA in men. Given the high degree of heterogeneity, stratified or adjusted analysis of effectiveness studies is indicated, taking genetics, sex and radiographic damage (sacroiliitis) into account.

Keyphrases

single cell
oxidative stress
randomized controlled trial
polycystic ovary syndrome
systematic review
ankylosing spondylitis
pregnancy outcomes
case control
type diabetes
pregnant women
adipose tissue
skeletal muscle
systemic lupus erythematosus