Potentials and Safety of Date Palm Fruit against Diabetes: A Critical Review.
Md Al-Tareq MiaMd Golam MosaibMd Ibrahim KhalilMd Asiful IslamSiew Hua GanPublished in: Foods (Basel, Switzerland) (2020)
Diabetes is a chronic metabolic disorder triggered by disturbances in carbohydrate, protein, and lipid metabolisms, where either reduced secretion or sensitivity of insulin is observed coupled with poor glucose control. Date palm fruits are one of the fruits reported to have good potential in diabetes treatment due to its presence of polyphenols exerting strong antioxidant activities. Other possible mechanisms of action include the polyphenolic compounds, which can inhibit enzymes like α-amylase and α-glucosidase. Flavonoids in dates can stimulate β-cells by increasing the number of islets and β-cells, recovering endocrine pancreatic tissues, reducing β-cell apoptosis, activating insulin receptors following the increase in insulin secretion, in addition to improving diabetes-induced complications. In this review, the in vitro, in vivo, and human study-based evidence of date palm as an anti-diabetic fruit is summarised.
Keyphrases
- type diabetes
- glycemic control
- cardiovascular disease
- induced apoptosis
- blood glucose
- cell cycle arrest
- endothelial cells
- signaling pathway
- oxidative stress
- cell proliferation
- insulin resistance
- gene expression
- endoplasmic reticulum stress
- blood pressure
- drug induced
- metabolic syndrome
- fatty acid
- molecular docking
- amino acid
- pi k akt
- pluripotent stem cells