EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.
Daniela PirriSiyu TianBlanca Tardajos-AyllonSophie E IrvingFrancesco DonatiScott P AllenTadanori MammotoGemma VilahurLida KabirJane BennettYasmin RasoolCharis PericleousGuianfranco MazzeiLiam McAllanWilliam R ScottThomas KoestlerUrs ZinggGraeme M BirdseyClint T MillerTorsten SchenkelEmily V ChambersMark J DunningJovana Serbanovic-CanicFrancesco BotreAkiko MammotoSuowen XuElena OstoWeiping HanMaria FragiadakiPaul C EvansPublished in: Circulation research (2024)
Endothelial EPAS1 attenuates atherosclerosis at sites of disturbed flow by maintaining EC proliferation via fatty acid uptake and metabolism. This endothelial repair pathway is inhibited in obesity, suggesting a novel triglyceride-PHD2 modulation pathway suppressing EPAS1 expression. These findings have implications for therapeutic strategies addressing vascular dysfunction in obesity.