High interindividual variability in LDL-cholesterol reductions after inclisiran administration in a real-world multicenter setting in Germany.

U MakhmudovaU SchatzN PerakakisU KassnerF SchumannC AxthelmP StürzebecherD L SinningA DoevelaarB RohnT WesthoffA VogtM SchollU KästnerJ-A GeilingK StachJ MenschE LorenzC PaitazoglouI EitelA BaesslerE Steinhagen-ThiessenW KoenigP C SchulzeU LandmesserU LaufsOliver Weingärtnernull null

Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)

In this real-world patient population referred to German lipid clinics for elevated LDL-C levels, inclisiran demonstrated a high interindividual variability in LDL-C reductions. Further research is warranted to elucidate reasons for the interindividual variability in drug efficacy.

Keyphrases

low density lipoprotein
primary care
case report
emergency department
cross sectional
clinical trial
fatty acid
adverse drug