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A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models.

Eric S LightcapPengfei YuStephen GrossmanKeli SongMithun KhattarKristina XegaXingyue HeJames M GavinHisashi ImaichiJames J GarnseyErik KoenigHongru ZhangZhen LuPooja ShahYu FuMichael A MilhollenBeryl A HattonJessica RicebergVaishali ShindeCong LiJames MinissaleXiaofeng YangDylan EnglandRichard A KlinghofferSteven P LangstonKatherine GalvinGary ShapiroSai M PulukuriSerge Y FuchsDennis Huszar
Published in: Science translational medicine (2021)
[Figure: see text].
Keyphrases
  • small molecule
  • immune response
  • protein protein
  • smoking cessation
  • cell therapy
  • dendritic cells
  • toll like receptor
  • stem cells
  • mesenchymal stem cells