Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses.

Minxian Wang Vivian S Lee-Kim Deepak S Atri Nadine H EloweJohn YuColin W GarvieHong-Hee WonJoseph E Hadaya Bryan T MacDonaldKevin TrindadeOlle MelanderDaniel James Rader Pradeep Natarajan Sekar KathiresanVirendar K KaushikAmit V Khera Rajat M Gupta

Published in: Circulation. Genomic and precision medicine (2021)

Functional testing of missense mutations improved the accuracy of rare variant association analysis. Despite compelling pathophysiology and a preliminary observation suggesting association, we observed no relationship between rare damaging variants in CORIN or circulating Corin concentrations with risk of CAD.

Keyphrases

coronary artery disease
copy number
single cell
percutaneous coronary intervention
cardiovascular events
coronary artery bypass grafting
heart failure
single molecule
circulating tumor
gene expression
acute coronary syndrome
dna methylation
autism spectrum disorder
left ventricular