Amit V Khera

Publication Activity (10 Years)

Years Active: 2019-2023
Publications (10 Years): 26

Top Topics

Body Mass Index

Cardiovascular Events

Drosophila Melanogaster

Top Venues

Circulation. Genomic and precision medicine

Nature communications

Nature genetics

This page only lists publications with an associated author ORCID identifier.

Publications

Reindert F Oostveen, Amit V Khera, Sekar Kathiresan, Erik S G Stroes, Kevin Fitzgerald, Matthew J Harms, Benjamin L Oakes, John J P Kastelein
New Approaches for Targeting PCSK9: Small-Interfering Ribonucleic Acid and Genome Editing. Arteriosclerosis, thrombosis, and vascular biology (2023)
Petko P Fiziev, Jeremy F McRae, Jacob C Ulirsch, Jacqueline S Dron, Tobias Hamp, Yanshen Yang, Pierrick Wainschtein, Zijian Ni, Joshua G Schraiber, Hong Gao, Dylan Cable, Yair Field, François Aguet, Marc Fasnacht, Ahmed A Metwally, Jeffrey Rogers, Tomas Marques-Bonet, Michael J Bamshad, Anne H O'Donnell-Luria, Amit V Khera, Kyle Kai-How Farh
Rare penetrant mutations confer severe risk of common diseases. Science (New York, N.Y.) 380 (6648) (2023)
Yiyi Zhang, Jacqueline S Dron, Brandon K Bellows, Amit V Khera, Junxiu Liu, Pallavi P Balte, Elizabeth C Oelsner, Sami Samir Amr, Matthew S Lebo, Anna Nagy, Gina M Peloso, Pradeep Natarajan, Jerome I Rotter, Cristen J Willer, Eric Boerwinkle, Christie M Ballantyne, Pamela L Lutsey, Myriam Fornage, Donald M Lloyd-Jones, Lifang Hou, Bruce M Psaty, Joshua C Bis, James S Floyd, Ramachandran S Vasan, Nancy L Heard-Costa, April P Carson, Michael E Hall, Stephen S Rich, Xiuqing Guo, Dhruv S Kazi, Sarah D de Ferranti, Andrew E Moran
Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease. Circulation 147 (20) (2023)
Aniruddh P Patel, Minxian Wang, Yunfeng Ruan, Satoshi Koyama, Shoa L Clarke, Xiong Yang, Catherine Tcheandjieu, Saaket Agrawal, Akl C Fahed, Patrick T Ellinor, null null, Philip S Tsao, Yan V Sun, Kelly Cho, Peter W F Wilson, Themistocles L Assimes, David A van Heel, Adam S Butterworth, Krishna G Aragam, Pradeep Natarajan, Amit V Khera
A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease. Nature medicine (2023)
Maria C Costanzo, Carolina Roselli, MacKenzie Brandes, Marc P Duby, Quy Hoang, Dongkeun Jang, Ryan Koesterer, Parul Kudtarkar, Annie Moriondo, Trang T Nguyen, Oliver Ruebenacker, Patrick Smadbeck, Ying Sun, Adam S Butterworth, Krishna G Aragam, R Thomas Lumbers, Amit V Khera, Steven A Lubitz, Patrick T Ellinor, Kyle J Gaulton, Jason Flannick, Noël P Burtt
Cardiovascular Disease Knowledge Portal: A Community Resource for Cardiovascular Disease Research. Circulation. Genomic and precision medicine (2023)
Yiyi Zhang, Jacqueline S Dron, Brandon K Bellows, Amit V Khera, Junxiu Liu, Pallavi P Balte, Elizabeth C Oelsner, Sami Samir Amr, Matthew S Lebo, Anna Nagy, Gina M Peloso, Pradeep Natarajan, Jerome I Rotter, Cristen J Willer, Eric Boerwinkle, Christie M Ballantyne, Pamela L Lutsey, Myriam Fornage, Donald M Lloyd-Jones, Lifang Hou, Bruce M Psaty, Joshua C Bis, James S Floyd, Ramachandran S Vasan, Nancy L Heard-Costa, April P Carson, Michael E Hall, Stephen S Rich, Xiuqing Guo, Dhruv S Kazi, Sarah D de Ferranti, Andrew E Moran
Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease. Circulation 147 (20) (2023)
Jeffrey D Wall, J Fah Sathirapongsasuti, Ravi Gupta, Asif Rasheed, Venkatesan Radha, Saurabh Belsare, Ramesh Menon, Sameer Phalke, Anuradha Mittal, John Z Fang, Deepak Tanneeru, Manjari Deshmukh, Akshi Bassi, Jacqueline A Robinson, Ruchi Chaudhary, Sakthivel Murugan, Zameer Ul-Asar, Imran Saleem, Unzila Ishtiaq, Areej Fatima, Saqib Shafi Sheikh, Shahid Hameed, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Anjum Jalal, Shahid Abbas, Philippe Frossard, Christian Fuchsberger, Lukas Forer, Sebastian Schoenherr, Qixin Bei, Tushar Bhangale, Jennifer Tom, Santosh Gopi Krishna Gadde, Priya B V, Naveen Kumar Naik, Minxian Wang, Pui-Yan Kwok, Amit V Khera, B R Lakshmi, Adam S Butterworth, Rajiv Chowdhury, John Danesh, Emanuele di Angelantonio, Aliya Naheed, Vinay Goyal, Rukmini M Kandadai, Hrishikesh Kumar, Rupam Borgohain, Adreesh Mukherjee, Pettarusp M Wadia, Ravi Yadav, Soaham Dilip Desai, Niraj Kumar, Atanu Biswas, Pramod Kumar Pal, Uday B Muthane, Shymal K Das, Vedam L Ramprasad, Prashanth Lingappa Kukkle, Somasekar Seshagiri, Sekar Kathiresan, Arkasubhra Ghosh, Viswanathan Mohan, Danish Saleheen, Eric W Stawiski, Andrew S Peterson
South Asian medical cohorts reveal strong founder effects and high rates of homozygosity. Nature communications 14 (1) (2023)
Dimitri J Maamari, Farouc A Jaffer, Amit V Khera, Akl C Fahed
CYP2C19 Genotyping in Anticoagulated Patients After Percutaneous Coronary Intervention: Should It Be Routine? Circulation 145 (10) (2022)
Amit V Khera, Minxian Wang, Mark D Chaffin, Connor A Emdin, Nilesh J Samani, Heribert Schunkert, Hugh C Watkins, Ruth McPherson, Roberto Elosua, Eric Boerwinkle, Diego Ardissino, Adam S Butterworth, Emanuele Di Angelantonio, Aliya Naheed, John Danesh, Rajiv Chowdhury, Harlan M Krumholz, Wayne Huey Herng Sheu, Stephen S Rich, Jerome I Rotter, Yii-Der Ida Chen, Stacey Gabriel, Eric S Lander, Danish Saleheen, Sekar Kathiresan
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Circulation. Genomic and precision medicine (2022)
Richard G Lee, Anne Marie Mazzola, Maurine C Braun, Colin Platt, Scott B Vafai, Sekar Kathiresan, Ellen Rohde, Andrew M Bellinger, Amit V Khera
Efficacy and Safety of an Investigational Single-course CRISPR Base Editing Therapy Targeting PCSK9 in Non-human Primate and Mouse Models. Circulation (2022)
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey B Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
Analyzing human knockouts to validate GPR151 as a therapeutic target for reduction of body mass index. PLoS genetics 18 (4) (2022)
Marijana Vujkovic, Shweta Ramdas, Kimberly Lorenz, Xiuqing Guo, Rebecca Darlay, Heather J Cordell, Jing He, Yevgeniy Gindin, Chuhan Chung, Robert P Myers, Carolin V Schneider, Joseph Park, Kyung Min Lee, Marina Serper, Rotonya M Carr, David E Kaplan, Mary E Haas, Matthew T MacLean, Walter R Witschey, Xiang Zhu, Catherine Tcheandjieu, Rachel L Kember, Henry R Kranzler, Anurag Verma, Ayush Giri, Derek M Klarin, Yan V Sun, Jie Huang, Jennifer E Huffman, Kate Townsend Creasy, Nicholas J Hand, Ching-Ti Liu, Michelle T Long, Jie Yao, Matthew J Budoff, Jingyi Tan, Xiaohui Li, Henry J Lin, Yii-Der Ida Chen, Kent D Taylor, Ruey-Kang Chang, Ronald M Krauss, Silvia Vilarinho, Joseph Brancale, Jonas B Nielsen, Adam E Locke, Marcus B Jones, Niek Verweij, Aris Baras, K Rajender Reddy, Brent A Neuschwander-Tetri, Jeffrey B Schwimmer, Arun J Sanyal, Naga Chalasani, Kathleen A Ryan, Braxton D Mitchell, Dipender Gill, Andrew D Wells, Elisabetta Manduchi, Yedidya Saiman, Nadim Mahmud, Donald R Miller, Peter D Reaven, Lawrence S Phillips, Sumitra Muralidhar, Scott L Duvall, Jennifer S Lee, Themistocles L Assimes, Saiju Pyarajan, Kelly Cho, Todd L Edwards, Scott M Damrauer, Peter W Wilson, J Michael Gaziano, Christopher J O'Donnell, Amit V Khera, Struan F A Grant, Christopher D Brown, Philip S Tsao, Danish Saleheen, Luca A Lotta, Lisa Bastarache, Quentin M Anstee, Ann K Daly, James B Meigs, Jerome I Rotter, Julie A Lynch, null null, null null, null null, null null, Daniel James Rader, Benjamin F Voight, Kyong-Mi Chang
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation. Nature genetics 54 (6) (2022)
Saaket Agrawal, Minxian Wang, Marcus D R Klarqvist, Kirk Smith, Joseph Shin, Hesam Dashti, Nathaniel Diamant, Seung Hoan Choi, Sean Joseph Jurgens, Patrick T Ellinor, Anthony Philippakis, Melina Claussnitzer, Kenney Ng, Miriam S Udler, Puneet Batra, Amit V Khera
Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots. Nature communications 13 (1) (2022)
Brandon K Bellows, Amit V Khera, Yiyi Zhang, Natalia Ruiz-Negrón, Henry M Stoddard, John B Wong, Dhruv S Kazi, Sarah D de Ferranti, Andrew E Moran
Estimated Yield of Screening for Heterozygous Familial Hypercholesterolemia With and Without Genetic Testing in US Adults. Journal of the American Heart Association 11 (11) (2022)
Aniruddh Pradip Patel, Amit V Khera
Response by Patel and Khera to Letter Regarding Article, "Quantifying and Understanding the Higher Risk of Atherosclerotic Cardiovascular Disease Among South Asian Individuals: Results From the UK Biobank Prospective Cohort Study". Circulation 145 (5) (2022)
Akl C Fahed, Anthony A Philippakis, Amit V Khera
The potential of polygenic scores to improve cost and efficiency of clinical trials. Nature communications 13 (1) (2022)
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn Olav Åsvold, Michael R Brown, Ben Michael Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daníel F Guðbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, null null, null null, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Shefali S Verma, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan L M Bjorkegren, Eric Boerwinkle, George Dedoussis, Hilma Hólm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kári Stefánsson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert J Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh C Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, null null
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nature genetics 54 (12) (2022)
Mengyao Shi, Wei Chen, Xiao Sun, Lydia A Bazzano, Jiang He, Alexander C Razavi, Changwei Li, Lu Qi, Amit V Khera, Tanika N Kelly
Association of Genome-Wide Polygenic Risk Score for Body Mass Index With Cardiometabolic Health From Childhood Through Midlife. Circulation. Genomic and precision medicine 15 (4) (2022)
Marcus D R Klarqvist, Saaket Agrawal, Nathaniel Diamant, Patrick T Ellinor, Anthony Philippakis, Kenney Ng, Puneet Batra, Amit V Khera
Silhouette images enable estimation of body fat distribution and associated cardiometabolic risk. NPJ digital medicine 5 (1) (2022)
Veryan Codd, Qingning Wang, Elias Allara, Crispin Musicha, Stephen Kaptoge, Svetlana Stoma, Tao Jiang, Stephen E Hamby, Peter S Braund, Vasiliki Bountziouka, Charley A Budgeon, Matthew Denniff, Chloe Swinfield, Manolo Papakonstantinou, Shilpi Sheth, Dominika E Nanus, Sophie C Warner, Minxian Wang, Amit V Khera, James M Eales, Willem Hendrik Ouwehand, John R Thompson, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, John N Danesh, Christopher P Nelson, Nilesh J Samani
Polygenic basis and biomedical consequences of telomere length variation. Nature genetics 53 (10) (2021)
Deanna G Brockman, Lia Petronio, Jacqueline S Dron, Bum Chul Kwon, Trish Vosburg, Lisa Nip, Andrew Tang, Mary O'Reilly, Niall Lennon, Bang Wong, Kenney Ng, Katherine H Huang, Akl C Fahed, Amit V Khera
Design and user experience testing of a polygenic score report: a qualitative study of prospective users. BMC medical genomics 14 (1) (2021)
Hannah Wand, Samuel A Lambert, Cecelia Tamburro, Michael A Iacocca, Jack W O'Sullivan, Catherine Sillari, Iftikhar J Kullo, Robb Rowley, Jacqueline S Dron, Deanna Brockman, Eric Venner, Mark I McCarthy, Antonis C Antoniou, Douglas F Easton, Robert A Hegele, Amit V Khera, Nilanjan Chatterjee, Charles Kooperberg, Karen Edwards, Katherine Vlessis, Kim Kinnear, John N Danesh, Helen Parkinson, Erin M Ramos, Megan C Roberts, Kelly E Ormond, Muin J Khoury, A Cecile J W Janssens, Katrina A B Goddard, Peter Kraft, Jacqueline A L MacArthur, Michael Inouye, Genevieve L Wojcik
Improving reporting standards for polygenic scores in risk prediction studies. Nature 591 (7849) (2021)
Minxian Wang, Vivian S Lee-Kim, Deepak S Atri, Nadine H Elowe, John Yu, Colin W Garvie, Hong-Hee Won, Joseph E Hadaya, Bryan T MacDonald, Kevin Trindade, Olle Melander, Daniel James Rader, Pradeep Natarajan, Sekar Kathiresan, Virendar K Kaushik, Amit V Khera, Rajat M Gupta
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses. Circulation. Genomic and precision medicine 14 (5) (2021)
Connor A Emdin, Mary E Haas, Amit V Khera, Krishna Aragam, Mark D Chaffin, Derek M Klarin, George Hindy, Lan Jiang, Wei-Qi Wei, QiPing Feng, Juha Karjalainen, Aki Samuli Havulinna, Tuomo Tapio Johannes Kiiskinen, Alexander G Bick, Diego Ardissino, James G Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J Bown, Nilesh J Samani, Usman Baber, Jeanette Erdmann, Namrata Gupta, John Danesh, Danish Saleheen, Kyong-Mi Chang, Marijana Vujkovic, Benjamin F Voight, Scott M Damrauer, Julie A Lynch, David E Kaplan, Marina Serper, Philip S Tsao, null null, Josep Maria Mercader, Craig L Hanis, Mark Daly, Joshua C Denny, Stacey Gabriel, Sekar Kathiresan
A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS genetics 16 (4) (2020)
Aniruddh Pradip Patel, Manish D Paranjpe, Nina P Kathiresan, Manuel A Rivas, Amit V Khera
Race, Socioeconomic Deprivation, and Hospitalization for COVID-19 in English participants of a National Biobank. medRxiv : the preprint server for health sciences (2020)
Julian R Homburger, Cynthia L Neben, Gilad Mishne, Alicia Y Zhou, Sekar Kathiresan, Amit V Khera
Low coverage whole genome sequencing enables accurate assessment of common variants and calculation of genome-wide polygenic scores. Genome medicine 11 (1) (2019)