Sekar Kathiresan

Publication Activity (10 Years)

Years Active: 2021-2023
Publications (10 Years): 11

Top Topics

Coronary Artery Disease

Top Venues

Nature communications

Circulation. Genomic and precision medicine

Nature genetics

This page only lists publications with an associated author ORCID identifier.

Publications

Reindert F Oostveen, Amit V Khera, Sekar Kathiresan, Erik S G Stroes, Kevin Fitzgerald, Matthew J Harms, Benjamin L Oakes, John J P Kastelein
New Approaches for Targeting PCSK9: Small-Interfering Ribonucleic Acid and Genome Editing. Arteriosclerosis, thrombosis, and vascular biology (2023)
Lisa N Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra Chadwick, Christopher Cheng, Sara P Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G Rajeev, Andrew M Bellinger
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy. Nature communications 14 (1) (2023)
Lisa N Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra Chadwick, Christopher Cheng, Sara P Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G Rajeev, Andrew M Bellinger
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy. Nature communications 14 (1) (2023)
Lisa N Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra Chadwick, Christopher Cheng, Sara P Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G Rajeev, Andrew M Bellinger
GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy. Nature communications 14 (1) (2023)
Amit V Khera, Minxian Wang, Mark D Chaffin, Connor A Emdin, Nilesh J Samani, Heribert Schunkert, Hugh C Watkins, Ruth McPherson, Roberto Elosua, Eric Boerwinkle, Diego Ardissino, Adam S Butterworth, Emanuele Di Angelantonio, Aliya Naheed, John Danesh, Rajiv Chowdhury, Harlan M Krumholz, Wayne Huey Herng Sheu, Stephen S Rich, Jerome I Rotter, Yii-Der Ida Chen, Stacey Gabriel, Eric S Lander, Danish Saleheen, Sekar Kathiresan
Gene Sequencing Identifies Perturbation in Nitric Oxide Signaling as a Nonlipid Molecular Subtype of Coronary Artery Disease. Circulation. Genomic and precision medicine (2022)
Richard G Lee, Anne Marie Mazzola, Maurine C Braun, Colin Platt, Scott B Vafai, Sekar Kathiresan, Ellen Rohde, Andrew M Bellinger, Amit V Khera
Efficacy and Safety of an Investigational Single-course CRISPR Base Editing Therapy Targeting PCSK9 in Non-human Primate and Mouse Models. Circulation (2022)
Manish D Paranjpe, Mark D Chaffin, Sohail Zahid, Scott C Ritchie, Jerome I Rotter, Stephen S Rich, Robert Gerszten, Xiuqing Guo, Susan R Heckbert, Russ Tracy, John Danesh, Eric S Lander, Michael Inouye, Sekar Kathiresan, Adam S Butterworth, Amit V Khera
Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease. PLoS genetics 18 (9) (2022)
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn Olav Åsvold, Michael R Brown, Ben Michael Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daníel F Guðbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, null null, null null, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Shefali S Verma, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan L M Bjorkegren, Eric Boerwinkle, George Dedoussis, Hilma Hólm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kári Stefánsson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert J Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh C Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, null null
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nature genetics 54 (12) (2022)
Kiran Musunuru, Alexandra C Chadwick, Taiji Mizoguchi, Sara P Garcia, Jamie E DeNizio, Caroline Wetherington Reiss, Kui Wang, Sowmya Iyer, Chaitali Dutta, Victoria Clendaniel, Michael Amaonye, Aaron Beach, Kathleen Berth, Souvik Biswas, Maurine C Braun, Huei-Mei Chen, Thomas V Colace, John D Ganey, Soumyashree A Gangopadhyay, Ryan Garrity, Lisa N Kasiewicz, Jennifer Lavoie, James A Madsen, Yuri Matsumoto, Anne Marie Mazzola, Yusuf S Nasrullah, Joseph Nneji, Huilan Ren, Athul Sanjeev, Madeleine Shay, Mary R Stahley, Steven H Y Fan, Ying K Tam, Nicole M Gaudelli, Giuseppe Ciaramella, Leslie E Stolz, Padma Malyala, Christopher J Cheng, Kallanthottathil G Rajeev, Ellen Rohde, Andrew M Bellinger, Sekar Kathiresan
In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates. Nature 593 (7859) (2021)
Scott C Ritchie, Samuel A Lambert, Matthew Arnold, Shu Mei Teo, Sol Lim, Petar Scepanovic, Jonathan Marten, Sohail Zahid, Mark D Chaffin, Yingying Liu, Gad Abraham, Willem Hendrik Ouwehand, David J Roberts, Nicholas A Watkins, Brian G Drew, Anna C Calkin, Emanuele Di Angelantonio, Nicole Soranzo, Stephen Burgess, Michael Chapman, Sekar Kathiresan, Amit V Khera, John Danesh, Adam S Butterworth, Michael Inouye
Integrative analysis of the plasma proteome and polygenic risk of cardiometabolic diseases. Nature metabolism 3 (11) (2021)
Minxian Wang, Vivian S Lee-Kim, Deepak S Atri, Nadine H Elowe, John Yu, Colin W Garvie, Hong-Hee Won, Joseph E Hadaya, Bryan T MacDonald, Kevin Trindade, Olle Melander, Daniel James Rader, Pradeep Natarajan, Sekar Kathiresan, Virendar K Kaushik, Amit V Khera, Rajat M Gupta
Rare, Damaging DNA Variants in CORIN and Risk of Coronary Artery Disease: Insights From Functional Genomics and Large-Scale Sequencing Analyses. Circulation. Genomic and precision medicine 14 (5) (2021)