AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Faten A SayedLay KodamaLi FanGillian K CarlingJoe C UdeochuDavid LeQingyun LiLu ZhouMan Ying WongRose HorowitzPearly YeHansruedi MathysMinghui WangXiang NiuLinas MazutisXueqiao JiangXueting WangFuying GaoMatthew B BrendelMaria A TelpoukhovskaiaTara E TracyGeorgia FrostYungui ZhouYaqiao LiYue QiuZuolin ChengGuoqiang YuJohn A HardyGiovanni CoppolaFei WangMichael A DeTureBin ZhangLei XieJohn Q TrojanowskiVirginia M Y LeeShiaoching GongSubhash C SinhaGourisankar GhoshWenjie LuoLi GanPublished in: Science translational medicine (2021)
[Figure: see text].