Virginia M Y Lee (Virginia Lee, Virginia M-Y Lee)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 37

Top Venues

Acta neuropathologica communications

Nature neuroscience

The Journal of neuroscience : the official journal of the Society for Neuroscience

NPJ Parkinson's disease

University of Pennsylvania

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pennsylvania

United States

Director - Center for Neurodegenerative Research :: Medicine/Pathology

Publications

Michael X Henderson, Medha Sengupta, John Q Trojanowski, Virginia M Y Lee
Correction to: Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta neuropathologica communications 12 (1) (2024)
Michael X Henderson, Medha Sengupta, John Q Trojanowski, Virginia M Y Lee
Correction to: Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta neuropathologica communications 12 (1) (2024)
Michael X Henderson, Medha Sengupta, John Q Trojanowski, Virginia M Y Lee
Correction to: Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta neuropathologica communications 12 (1) (2024)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Norihito Uemura, Nicholas P Marotta, Jahan Ara, Emily S Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Q Trojanowski, Virginia M Y Lee
α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice. Nature communications 14 (1) (2023)
Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivanna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderson
Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease. NPJ Parkinson's disease 9 (1) (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience 26 (2) (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Author Correction: Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience 26 (2) (2023)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Xinyi Zhao, Wen Zeng, Hong Xu, Zihan Sun, Yingxin Hu, Beibei Peng, Jennifer D McBride, Jiangtao Duan, Juan Deng, Bin Zhang, Soo-Jung Kim, Bryan Zoll, Takashi Saito, Hiroki Sasaguri, Takaomi C Saido, Carlo Ballatore, Haishan Yao, Zhaoyin Wang, John Q Trojanowski, Kurt R Brunden, Virginia M Y Lee, Zhuohao He
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury. Science translational medicine 15 (713) (2023)
Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivanna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderson
Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease. NPJ Parkinson's disease 9 (1) (2023)
Senthil T Kumar, Sergey Nazarov, Sílvia Porta, Niran Maharjan, Urszula Cendrowska, Malek Kabani, Francesco Finamore, Yan Xu, Virginia M Y Lee, Hilal A Lashuel
Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage. Nature neuroscience (2023)
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F Olufemi, Ronald J Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K Williams, Shino Magaki, Harry V Vinters, Hilal A Lashuel, Benjamin A Garcia, E James Petersson, John Q Trojanowski, Virginia M Y Lee, Chao Peng
Post-translational modifications of soluble α-synuclein regulate the amplification of pathological α-synuclein. Nature neuroscience 26 (2) (2023)
Zi-Yang Zhang, Dilshan S Harischandra, Ruifang Wang, Shivani Ghaisas, Janet Y Zhao, Thomas P McMonagle, Guixin Zhu, Kenzo D Lacuarta, Jianing Song, John Q Trojanowski, Hong Xu, Virginia M Y Lee, Xiaolu Yang
TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease. Science (New York, N.Y.) 381 (6656) (2023)
Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivanna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderson
Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease. NPJ Parkinson's disease 9 (1) (2023)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Cheryl E G Leyns, Alice Prigent, Brenna Beezhold, Lihang Yao, Nathan G Hatcher, Peining Tao, John Kang, EunRan Suh, Vivanna M Van Deerlin, John Q Trojanowski, Virginia M Y Lee, Matthew E Kennedy, Matthew J Fell, Michael X Henderson
Glucocerebrosidase activity and lipid levels are related to protein pathologies in Parkinson's disease. NPJ Parkinson's disease 9 (1) (2023)
Norihito Uemura, Nicholas Marotta, Jahan Ara, Emily Meymand, Bin Zhang, Hiroshi Kameda, Masato Koike, Kelvin C Luk, John Trojanowski, Virginia M Y Lee
Distinct biological activity of Lewy body α-Synuclein strain in mice. Research square (2023)
Celeste Parra Bravo, Alice Maria Giani, Jesus Madero Perez, Zeping Zhao, Avi Samelson, Man Ying Wong, Alessandro Evangelisti, Li Fan, Tatyana Pozner, Maria Mercedes, Pearly Ye, Tark Patel, Allan Yarahmady, Gillian K Carling, Virginia M Y Lee, Manu Sharma, Sue-Ann Mok, Wenjie Luo, Mingrui Zhao, Martin Edward Kampmann, Shiaoching Gong, Li Gan
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. bioRxiv : the preprint server for biology (2023)
Seong Kwon Hur, Mandana Hunter, Myrna A Dominique, Madona Farag, Dejania Cotton-Samuel, Tahiyana Khan, John Q Trojanowski, Krista J Spiller, Virginia M Y Lee
Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis. Acta neuropathologica communications 10 (1) (2022)
Nicholas P Marotta, Jahan Ara, Norihito Uemura, Marshall G Lougee, Emily S Meymand, Bin Zhang, E James Petersson, John Q Trojanowski, Virginia M Y Lee
Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro. Acta neuropathologica communications 9 (1) (2021)
Faten A Sayed, Lay Kodama, Li Fan, Gillian K Carling, Joe C Udeochu, David Le, Qingyun Li, Lu Zhou, Man Ying Wong, Rose Horowitz, Pearly Ye, Hansruedi Mathys, Minghui Wang, Xiang Niu, Linas Mazutis, Xueqiao Jiang, Xueting Wang, Fuying Gao, Matthew B Brendel, Maria A Telpoukhovskaia, Tara E Tracy, Georgia Frost, Yungui Zhou, Yaqiao Li, Yue Qiu, Zuolin Cheng, Guoqiang Yu, John A Hardy, Giovanni Coppola, Fei Wang, Michael A DeTure, Bin Zhang, Lei Xie, John Q Trojanowski, Virginia M Y Lee, Shiaoching Gong, Subhash C Sinha, Gourisankar Ghosh, Wenjie Luo, Li Gan
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science translational medicine 13 (622) (2021)
Qihui Wu, Muhammad A Shaikh, Emily S Meymand, Bin Zhang, Kelvin C Luk, John Q Trojanowski, Virginia M Y Lee
Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta neuropathologica 140 (6) (2020)
Chao Peng, John Q Trojanowski, Virginia M Y Lee
Protein transmission in neurodegenerative disease. Nature reviews. Neurology 16 (4) (2020)
Michael X Henderson, Medha Sengupta, John Q Trojanowski, Virginia M Y Lee
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta neuropathologica communications 7 (1) (2019)
Joomyung V Jun, Conor M Haney, Richard J Karpowicz, Sam Giannakoulias, Virginia M Y Lee, E James Petersson, David M Chenoweth
A "Clickable" Photoconvertible Small Fluorescent Molecule as a Minimalist Probe for Tracking Individual Biomolecule Complexes. Journal of the American Chemical Society 141 (5) (2019)
Qihui Wu, Hajime Takano, Dawn M Riddle, John Q Trojanowski, Douglas A Coulter, Virginia M Y Lee
α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 39 (26) (2019)
Rizwan S Akhtar, Joseph P Licata, Kelvin C Luk, Leslie M Shaw, John Q Trojanowski, Virginia M Y Lee
Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of neurochemistry 145 (6) (2018)
Michael X Henderson, Chao Peng, John Q Trojanowski, Virginia M Y Lee
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons. Acta neuropathologica communications 6 (1) (2018)
Heidi Martini-Stoica, Allysa L Cole, Daniel B Swartzlander, Fading Chen, Ying-Wooi Wan, Lakshya Bajaj, David A Bader, Virginia M Y Lee, John Q Trojanowski, Zhandong Liu, Marco Sardiello, Hui Zheng
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of experimental medicine 215 (9) (2018)
Garrett S Gibbons, Rachel A Banks, Bumjin Kim, Hong Xu, Lakshmi Changolkar, Susan N Leight, Dawn M Riddle, Chi Li, Ronald J Gathagan, Hannah J Brown, Bin Zhang, John Q Trojanowski, Virginia M Y Lee
GFP-Mutant Human Tau Transgenic Mice Develop Tauopathy Following CNS Injections of Alzheimer's Brain-Derived Pathological Tau or Synthetic Mutant Human Tau Fibrils. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (47) (2017)
Sneha Narasimhan, Jing L Guo, Lakshmi Changolkar, Anna Stieber, Jennifer D McBride, Luisa V Silva, Zhuohao He, Bin Zhang, Ronald J Gathagan, John Q Trojanowski, Virginia M Y Lee
Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (47) (2017)
Krista J Spiller, Claudia J Cheung, Clark R Restrepo, Linda K Kwong, Anna M Stieber, John Q Trojanowski, Virginia M Y Lee
Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (29) (2017)
Michael X Henderson, Charlotte Hiu-Yan Chung, Dawn M Riddle, Bin Zhang, Ronald J Gathagan, Steven H Seeholzer, John Q Trojanowski, Virginia M Y Lee
Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (24) (2017)
Jing L Guo, Sneha Narasimhan, Lakshmi Changolkar, Zhuohao He, Anna Stieber, Bin Zhang, Ronald J Gathagan, Michiyo Iba, Jennifer D McBride, John Q Trojanowski, Virginia M Y Lee
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of experimental medicine 213 (12) (2016)

Virginia M Y Lee.css-eqlu8i{font-size:small;padding-left:4px;} (Virginia Lee, Virginia M-Y Lee)

Publication Activity (10 Years)

Top Topics

Top Venues

Virginia M Y Lee (Virginia Lee, Virginia M-Y Lee)