Surface Engineering of Magnetic Iron Oxide Nanoparticles for Breast Cancer Diagnostics and Drug Delivery.
Mengjie XieFansu MengPanpan WangAlicia Marcelina Díaz-GarcíaMarina ParkhatsRalph Santos-OliveiraMulazim Hussain AsimNazish BostanHonghui GuLina YangQi LiZhenjiang YangHaibiao LaiYu CaiPublished in: International journal of nanomedicine (2024)
Data published in 2020 by the International Agency for Research on Cancer (IARC) of the World Health Organization show that breast cancer (BC) has become the most common cancer globally, affecting more than 2 million women each year. The complex tumor microenvironment, drug resistance, metastasis, and poor prognosis constitute the primary challenges in the current diagnosis and treatment of BC. Magnetic iron oxide nanoparticles (MIONPs) have emerged as a promising nanoplatform for diagnostic tumor imaging as well as therapeutic drug-targeted delivery due to their unique physicochemical properties. The extensive surface engineering has given rise to multifunctionalized MIONPs. In this review, the latest advancements in surface modification strategies of MIONPs over the past five years are summarized and categorized as constrast agents and drug delivery platforms. Additionally, the remaining challenges and future prospects of MIONPs-based targeted delivery are discussed.
Keyphrases
- iron oxide nanoparticles
- poor prognosis
- drug delivery
- papillary thyroid
- cancer therapy
- long non coding rna
- squamous cell
- molecularly imprinted
- current status
- drug release
- photodynamic therapy
- randomized controlled trial
- squamous cell carcinoma
- breast cancer risk
- machine learning
- metabolic syndrome
- young adults
- mass spectrometry
- big data
- skeletal muscle
- insulin resistance
- pregnancy outcomes
- fluorescence imaging
- meta analyses