Exercise and Metformin Intervention Prevents Lipotoxicity-Induced Hepatocyte Apoptosis by Alleviating Oxidative and ER Stress and Activating the AMPK/Nrf2/HO-1 Signaling Pathway in db/db Mice.
Yuan ZhangYuting LiuXiaowei LiuXinmeng YuanMengqi XiangJingjing LiuLiumei ZhangShouqian ZhuJiao LuQiang TangSulin ChengPublished in: Oxidative medicine and cellular longevity (2022)
-ATF4 pathway. Furthermore, upregulation of AMPK-Nrf2-HO-1 signaling pathway might be a key crosstalk between MET and exercise, which may have additive effects on alleviating hepatic lipid accumulation.
Keyphrases
- signaling pathway
- pi k akt
- cell cycle arrest
- oxidative stress
- high intensity
- diabetic rats
- endoplasmic reticulum stress
- induced apoptosis
- epithelial mesenchymal transition
- skeletal muscle
- physical activity
- randomized controlled trial
- resistance training
- cell proliferation
- drug induced
- liver injury
- protein kinase
- tyrosine kinase
- transcription factor
- high fat diet induced
- cell death
- poor prognosis
- type diabetes
- insulin resistance
- adipose tissue
- endothelial cells