Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer.
Matteo MorottiChristos E ZoisRokaya El-AnsariMadeleine L CrazeEmad A RakhaShih-Jung FanAlessandro ValliSyed HaiderDeborah C I GoberdhanAndrew R GreenAdrian L HarrisPublished in: British journal of cancer (2020)
These results position SLC38A2 as a selective target for inhibiting growth of Gln-dependent breast cancer cell lines.