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Novel mouse model expands potential human α-cell research.

Theodore Dos SantosPatrick Edward MacDonald
Published in: Islets (2021)
A glucagon knock-out mouse with preserved GLP-1 and GLP-2 secretion allows for the improved study of transplanted human islets and glucagon responses- providing an unprecedented resource in human α-cell and diabetes research.
Keyphrases
  • endothelial cells
  • mouse model
  • induced pluripotent stem cells
  • single cell
  • type diabetes
  • pluripotent stem cells
  • cell therapy
  • cardiovascular disease
  • adipose tissue
  • bone marrow
  • mesenchymal stem cells
  • weight loss