Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy.
Xiaohui BianTomás P GriffinXiangyang ZhuMd Nahidul IslamSabena M ConleyAlfonso EirinHui TangPaula M O'SheaAllyson K PalmerRozalina Grubina McCoySandra M HerrmannRamila A MehtaJohn R WoollardAndrew D RuleJames L KirklandTamar TchkoniaStephen C TextorMatthew D GriffinLilach Orly LermanLaTonya J HicksonPublished in: BMJ open diabetes research & care (2019)
Circulating activin A is increased in human DKD and correlates with reduced kidney function and kidney injury markers. DKD-injured human renal tubule cells develop a profibrotic and inflammatory phenotype with activin A upregulation. These findings underscore the role of inflammation and provide a basis for further exploration of activin A as a diagnostic marker and therapeutic target in DKD.