Reversal of obesity development in Ceacam1 -/- male mice by bone marrow transplantation or introduction of the human CEACAM1 gene.

Zhifang ZhangDeirdre La PlacaGabriel GugiuAlyssa ThunenKeith LeJohn E Shively

Published in: Obesity (Silver Spring, Md.) (2022)

CEACAM1 expression in both the liver and immune cells regulates obesity and lipid storage pathways in the liver. Bone marrow reconstitution of the immune system or introduction of the human CEACAM1 gene can fully or partially reverse the phenotype.

Keyphrases

bone marrow
endothelial cells
metabolic syndrome
insulin resistance
mesenchymal stem cells
weight loss
type diabetes
induced pluripotent stem cells
genome wide
poor prognosis
copy number
weight gain
high fat diet induced
pluripotent stem cells
body mass index
adipose tissue
stem cells
dna methylation
binding protein