Remarkable Enhancement in Boron Uptake Within Glioblastoma Cells With Carboranyl-Indole Carboxamides.
Rajeshwar NarlawarChristopher J D AustinJan KahlertSilvia SelleriEleonora Da PozzoClaudia MartiniEryn L WerryLouis M RendinaMichael KassiouPublished in: Chemistry, an Asian journal (2018)
Novel boron-rich, carboranyl-indole carboxamide ligands were prepared and found to effectively target the 18 kDa translocator protein (TSPO), an upregulated mitochondrial membrane-bound protein which has been observed in variety of tumor cell lines and its expression appears to be proportional to the degree of tumorigenicity, emphasizing a key role in cancer cell proliferation. Both boronated compounds displayed remarkably high affinities for the TSPO. In addition, the in vitro uptake of these compounds into T98G human glioma cells was found to be 25- to 100-fold greater than that of clinical boron neutron capture therapy (BNCT) agents.
Keyphrases
- cell proliferation
- binding protein
- induced apoptosis
- endothelial cells
- poor prognosis
- protein protein
- pet imaging
- oxidative stress
- papillary thyroid
- amino acid
- cell cycle arrest
- cell cycle
- stem cells
- squamous cell
- induced pluripotent stem cells
- heat shock protein
- cell death
- computed tomography
- pluripotent stem cells
- cell therapy