Boswellic acid protects against Bisphenol-A and gamma radiation induced hepatic steatosis and cardiac remodelling in rats: role of hepatic PPAR-α/P38 and cardiac Calcineurin-A/NFATc1/P38 pathways.
Noura M ThabetMohamed Khairy Abdel-RafeiEnas Mahmoud MoustafaPublished in: Archives of physiology and biochemistry (2020)
Bisphenol-A (BPA) and gamma-radiation are two risky environmental pollutants that human beings are exposed to in everyday life and consequently they threaten human health via inducing oxidative stress, inflammation, and eventually tissue damage. This study aims at appraising the protective effect of Boswellic Acid (BA) (250 mg/kg/day, orally) administration on BPA (150 mg/kg/day, i.p) and γ-irradiation (IR) (3 Gy/week for 4 weeks up to cumulative dose of 12 Gy/experimental course) for 4 weeks-induced damage to liver and heart tissues of rats. The present results indicated a significant improvement against damage induced by BPA and IR revealed in biochemical investigations (hepatic PPAR-α/P38 and cardiac ET-1/Calcineurin-A/NFATc1/P38) and histopathological examination of liver and heart. It could be concluded that BA possesses a protective effect against these two deleterious environmental pollutants which attracted major global concerns due to their serious toxicological impact on human health.
Keyphrases
- human health
- oxidative stress
- radiation induced
- risk assessment
- diabetic rats
- climate change
- heavy metals
- left ventricular
- radiation therapy
- heart failure
- dna damage
- endothelial cells
- atrial fibrillation
- ischemia reperfusion injury
- insulin resistance
- gene expression
- high glucose
- induced apoptosis
- single cell
- type diabetes
- randomized controlled trial
- fatty acid
- metabolic syndrome
- life cycle