FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms.
Katarina Stoklund DittlauLisanne TerriePieter BaatsenAxelle KerstensLim De SwertRekin's JankyNikky CorthoutPegah MasroriPhilip Van DammePoul HyttelMorten MeyerLieven ThorrezKristine Karla FreudeLudo Van Den BoschPublished in: Molecular neurodegeneration (2023)
Our findings shine light on a complex, yet highly important role of astrocytes in ALS, and provides further insight in to their pathological mechanisms.