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FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms.

Katarina Stoklund DittlauLisanne TerriePieter BaatsenAxelle KerstensLim De SwertRekin's JankyNikky CorthoutPegah MasroriPhilip Van DammePoul HyttelMorten MeyerLieven ThorrezKristine Karla FreudeLudo Van Den Bosch
Published in: Molecular neurodegeneration (2023)
Our findings shine light on a complex, yet highly important role of astrocytes in ALS, and provides further insight in to their pathological mechanisms.
Keyphrases
  • amyotrophic lateral sclerosis
  • endothelial cells
  • oxidative stress
  • induced pluripotent stem cells
  • pluripotent stem cells