Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI-induced hypogonadism?
Rastafa I GeddesAmita KapoorKentaro HayashiRyan RauhMarlyse WehberQuinn BongersAlex D JansenIcelle M AndersonGabrielle FarquharSivan Vadakkadath-MeethalToni E ZieglerCraig S AtwoodPublished in: Endocrinology, diabetes & metabolism (2021)
Together, these data indicate that (1) craniectomy is sufficient to induce persistent hypogonadism and hypoadrenalism, (2) hCG can reverse hypogonadism induced by a craniectomy or craniectomy +CCI injury, suggesting that (3) craniectomy and CCI injury induce a persistent hypogonadism by decreasing hypothalamic and/or pituitary function rather than testicular function in male rats. The potential role of hCG as a cheap, safe and readily available treatment for reversing surgery or TBI-induced hypogonadism is discussed.
Keyphrases
- traumatic brain injury
- replacement therapy
- severe traumatic brain injury
- neuropathic pain
- high glucose
- smoking cessation
- diabetic rats
- minimally invasive
- coronary artery disease
- white matter
- big data
- spinal cord
- machine learning
- human health
- resting state
- electronic health record
- oxidative stress
- spinal cord injury
- blood brain barrier
- germ cell
- brain injury
- functional connectivity
- induced pluripotent stem cells
- cerebral ischemia
- heat stress
- mild traumatic brain injury
- surgical site infection
- deep learning
- pluripotent stem cells