MicroRNA 452 regulates SHC1 expression in human colorectal cancer and colitis.

Ji-Su MoSantosh LamichhaneKi-Jung YunSoo Cheon Chae

Published in: Genes & genomics (2023)

These findings suggest a potential defense mechanism in which MIR452 regulation of the adaptor protein SHC1 maintains cellular homeostasis during carcinogenesis or chronic inflammation. Therefore, MIR452 may have therapeutic value for human early-stage CRC and colitis.

Keyphrases

endothelial cells
early stage
long non coding rna
cell proliferation
poor prognosis
induced pluripotent stem cells
pluripotent stem cells
oxidative stress
radiation therapy
small molecule
climate change
protein protein
rectal cancer
innate immune